(S)-2-((S)-2-Benzylamino-propionylamino)-3-methyl-butyric acid benzyl ester

Base Information

Chemical Name:(S)-2-((S)-2-Benzylamino-propionylamino)-3-methyl-butyric acid benzyl ester
CAS No.:924727-24-2
Molecular Formula:C₂₂H₂₈N₂O₃
Molecular Weight:368.476
Hs Code.:

Synonyms:(S)-2-((S)-2-Benzylamino-propionylamino)-3-methyl-butyric acid benzyl ester

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Chemical Property of (S)-2-((S)-2-Benzylamino-propionylamino)-3-methyl-butyric acid benzyl ester

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Technology Process of (S)-2-((S)-2-Benzylamino-propionylamino)-3-methyl-butyric acid benzyl ester

There total 2 articles about (S)-2-((S)-2-Benzylamino-propionylamino)-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 924727-23-1
Boc-N(Bzl)Ala-Val-OBzl

: 924727-24-2
(S)-2-((S)-2-Benzylamino-propionylamino)-3-methyl-butyric acid benzyl ester

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 0.5h;
DOI:10.1021/jm058038f

Reference yield:

: 159999-80-1
N-benzyl-N-Boc-L-alanine

: 924727-24-2
(S)-2-((S)-2-Benzylamino-propionylamino)-3-methyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxybenzotriazole; 2-1H-(benzotriazole-1-yl)-1,1,3,3-tetramethyluronium BF₄^(1-); diisopropylethylamine / CH₂Cl₂ / 0.33 h

1.2: 85.6 percent / DIPEA / CH₂Cl₂ / 72 h

2.1: 70 percent / aq. HCl / ethyl acetate / 0.5 h

With hydrogenchloride; HBTU; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate;
DOI:10.1021/jm058038f

Reference yield:

: 924727-24-2
(S)-2-((S)-2-Benzylamino-propionylamino)-3-methyl-butyric acid benzyl ester

: Boc-Tyr(Bzl)-N(Bzl)Ala-Val-OH

Guidance literature:: Multi-step reaction with 2 steps

1: 0.746 mg / N-methylmorpholine / CH₂Cl₂ / -10 - 20 °C

2: 95.1 percent / H₂ / Pd/C / methanol / 3 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm058038f