<1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S,6R)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol

Base Information

Chemical Name:<1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol
CAS No.:130710-65-5
Molecular Formula:C₃₉H₅₆O₄Si
Molecular Weight:616.957
Hs Code.:

<1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol

Synonyms:<1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol

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Chemical Property of <1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol

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Technology Process of <1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol

There total 12 articles about <1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 130710-64-4
(1R,3S,7R,8R,8aS)-3-Ethyl-8-{2-[(4R,6S)-6-(2-hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 130710-65-5
<1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol

Guidance literature:: With triethylamine; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; In dichloromethane; for 24h; Ambient temperature;

Reference yield:

: 130710-60-0
(R)-α-<(1,3-dioxolan-2-yl)methyl>butanal

: 130710-65-5
<1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) 1.6 M butyl-lithium / 1.) hexane, THF, -6 to 0 deg C, 1 h, 2.) 0 deg C, 20 min

2: 65 percent / 10 percent v/v aq. hydrochloric acid / diethyl ether / 26 h / Ambient temperature

3: 1.) LDA / 1.) diethyl ether, -78 deg C, 45 min, 2.) diethyl ether, -78 deg C, 10 min

4: 92 percent Turnov_. / di-isopropylamine, 4-(dimethylamino)pyridine / diethyl ether / 1.) 0 deg C, 30 min, 2.) room temperature, 40 h

5: 1.) ozone, 2.) triphenylphosphine / 1.) dichloromethane, -78 deg C, 1 min, 2.) --> room temperature, 3 h

6: 89 percent / potassium graphite, titanium trichloride / 1,2-dimethoxy-ethane / 1.) room temperature, 5 h, 2.) reflux, 5 h

7: 96 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 22 h / Ambient temperature

8: 97 percent / triethylamine / DMPA / CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; dmap; n-butyllithium; titanium(III) chloride; potassium graphite; tetrabutyl ammonium fluoride; ozone; triethylamine; diisopropylamine; triphenylphosphine; lithium diisopropyl amide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane;

Reference yield:

: 130710-62-2
(R)-3-ethylpent-4-enal

: 130710-65-5
<1S(1α,3α,7β,8β,8aβ)>-8-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-3-ethyl-1,2,3,7,8,8a-hexahydro-7-methylnaphthalen-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA / 1.) diethyl ether, -78 deg C, 45 min, 2.) diethyl ether, -78 deg C, 10 min

2: 92 percent Turnov_. / di-isopropylamine, 4-(dimethylamino)pyridine / diethyl ether / 1.) 0 deg C, 30 min, 2.) room temperature, 40 h

3: 1.) ozone, 2.) triphenylphosphine / 1.) dichloromethane, -78 deg C, 1 min, 2.) --> room temperature, 3 h

4: 89 percent / potassium graphite, titanium trichloride / 1,2-dimethoxy-ethane / 1.) room temperature, 5 h, 2.) reflux, 5 h

5: 96 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 22 h / Ambient temperature

6: 97 percent / triethylamine / DMPA / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; titanium(III) chloride; potassium graphite; tetrabutyl ammonium fluoride; ozone; triethylamine; diisopropylamine; triphenylphosphine; lithium diisopropyl amide; 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane;