4-tert-butyl-N-[6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide

Base Information

• Chemical Name: 4-tert-butyl-N-[6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
• CAS No.: 1632289-55-4
• Molecular Formula: C₂₈H₃₁N₅O₇S
• Molecular Weight: 581.649
• Mol file: 1632289-55-4.mol

Synonyms:4-tert-butyl-N-[6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide

Chemical Property of 4-tert-butyl-N-[6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-tert-butyl-N-[6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide

There total 4 articles about 4-tert-butyl-N-[6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-tert-butyl-N-{6-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl}benzenesulfonamide (1632289-54-3) → 4-tert-butyl-N-[6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide (1632289-55-4)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; at 20 ℃; for 5h;

DOI:10.1055/s-0033-1340281

Reference yield:

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide (150727-06-3) → 4-tert-butyl-N-[6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide (1632289-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / acetonitrile / 4 h / 80 - 85 °C

1.2: 8 h

2.1: hydrogenchloride / acetonitrile; water / 5 h / 20 °C

With hydrogenchloride; sodium hydroxide; In water; acetonitrile;

DOI:10.1055/s-0033-1340281

Reference yield:

4-tert-butylbenzenesulphonamide (6292-59-7) → 4-tert-butyl-N-[6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide (1632289-55-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / toluene / 0.5 h / 50 °C / Large scale

1.2: 10 h / 110 °C / Large scale

2.1: sodium hydroxide / acetonitrile / 4 h / 80 - 85 °C

2.2: 8 h

3.1: hydrogenchloride / acetonitrile; water / 5 h / 20 °C

With hydrogenchloride; potassium carbonate; sodium hydroxide; In water; toluene; acetonitrile;

DOI:10.1055/s-0033-1340281

upstream raw materials:

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenoxy)2,2'-bipyrimidin-4-yl)benzene sulfonamide

4-tert-butylbenzenesulphonamide

C₁₅H₁₁ClN₄O₃

4-tert-butyl-N-{6-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl}benzenesulfonamide

Downstream raw materials:

4-tert-butyl-N-(5-(2-methoxyphenoxy)-6-(2-oxoethoxy)-2,2′-bipyrimidin-4-yl)benzenesulfonamide