Chemical Property of BLASTICIDIN S HYDROCHLORIDE
Chemical Property:
- Vapor Pressure:4.07E-26mmHg at 25°C
- Melting Point:224-225 °C (decomp)
- Boiling Point:772.1°C at 760 mmHg
- Flash Point:420.8°C
- PSA：215.67000
- LogP:1.05570
- Storage Temp.:−20°C
- Solubility.:Soluble in Water (greater than 25 mg/ml)
- Water Solubility.:Soluble in water. Insoluble in organic solvents.
- Purity/Quality:
-
99% *data from raw suppliers
BlasticidinSHydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
T+
- Hazard Codes:T+
- Statements:
28
- Safety Statements:
28-36/37-45
- MSDS Files:
-
SDS file from LookChem
Useful:
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Description
Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4
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Uses
Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation. Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis. Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.
