BLASTICIDIN S HYDROCHLORIDE

Base Information

• Chemical Name: BLASTICIDIN S HYDROCHLORIDE
• CAS No.: 3513-03-9
• Molecular Formula: C17H26 N8 O5 . Cl H
• Molecular Weight: 458.9
• Hs Code.: 29349990
• Mol file: 3513-03-9.mol

Synonyms:BlasticidinS, monohydrochloride (8CI); Blasticidin S hydrochloride

Chemical Property of BLASTICIDIN S HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 4.07E-26mmHg at 25°C
• Melting Point: 224-225 °C (decomp)
• Boiling Point: 772.1°C at 760 mmHg
• Flash Point: 420.8°C
• PSA: 215.67000
• LogP: 1.05570
• Storage Temp.: −20°C
• Solubility.: Soluble in Water (greater than 25 mg/ml)
• Water Solubility.: Soluble in water. Insoluble in organic solvents.

Purity/Quality:

99%, ^*data from raw suppliers

BlasticidinSHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 28
• Safety Statements: 28-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Description: Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4
• Uses: Inhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation. Blasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis. Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.