?-(+)-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: ?-(+)-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE
• CAS No.: 82572-04-1
• Molecular Formula: C12H13 N . Cl H
• Molecular Weight: 207.703
• Hs Code.: 2921499090
• Mol file: 82572-04-1.mol

Synonyms:1-Naphthalenemethanamine,a-methyl-, hydrochloride, (R)-;1-Naphthalenemethanamine, a-methyl-, hydrochloride, (aR)- (9CI); (R)-1-(1-Naphthyl)ethylamine hydrochloride

Chemical Property of ?-(+)-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 9.54E-05mmHg at 25°C
• Melting Point: 253-257oC(lit.)
• Boiling Point: 333.9°C at 760 mmHg
• Flash Point: 155.7°C
• PSA: 26.02000
• LogP: 4.36180
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

(R)-1-(Naphthalen-1-yl)ethanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-36/37/38-50
• Safety Statements: 26-60-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ?-(+)-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE

There total 3 articles about ?-(+)-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1R)-1-(naphthalen-1-yl)ethanamine (R)-mandelate (1073144-62-3) → (R)-<1-(1-Naphthyl)ethyl>ammonium chloride (82572-04-1)

Guidance literature:

(1R)-1-(naphthalen-1-yl)ethanamine (R)-mandelate; With ammonia; In water; toluene;

With hydrogenchloride; In ethyl acetate; isopropyl alcohol; at 10 - 15 ℃; pH=3 - 4;

DOI:10.1080/00397910903538651

Reference yield:

1'-naphthacetophenone (941-98-0) → (R)-<1-(1-Naphthyl)ethyl>ammonium chloride (82572-04-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 20 - 35 °C / pH 6 - 6.5

2.1: ammonia; hydrogen / methanol; water / 58 - 62 °C / 2574.5 - 2942.29 Torr

3.1: ethanol / 0.75 h / 60 - 65 °C / Resolution of racemate

4.1: ammonia / water; toluene

4.2: 10 - 15 °C / pH 3 - 4

With hydroxylamine hydrochloride; ammonia; hydrogen; sodium hydroxide; In methanol; ethanol; water; toluene;

DOI:10.1080/00397910903538651

Reference yield:

1-(1-naphthalenyl)ethanone oxime (1956-40-7,100485-51-6,100485-59-4) → (R)-<1-(1-Naphthyl)ethyl>ammonium chloride (82572-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonia; hydrogen / methanol; water / 58 - 62 °C / 2574.5 - 2942.29 Torr

2.1: ethanol / 0.75 h / 60 - 65 °C / Resolution of racemate

3.1: ammonia / water; toluene

3.2: 10 - 15 °C / pH 3 - 4

With ammonia; hydrogen; In methanol; ethanol; water; toluene;

DOI:10.1080/00397910903538651

upstream raw materials:

1'-naphthacetophenone

(1R)-1-(naphthalen-1-yl)ethanamine (R)-mandelate

1-(1-naphthalenyl)ethanone oxime

Downstream raw materials:

3-{[(1R)-1-(naphthalen-1-yl)ethyl]amino}-1-[3-(trifluoromethyl)phenyl]propan-1-one hydrochloride

benzyl-(1-naphthalen-1-yl-ethyl)-amine hydrochloride

cinacalcet hydrochloride

(R)-N-(4-methoxybenzyl)-1-(1-naphthyl)ethylamine hydrochloride

Refernces