2-benzylacrylaMide

Base Information

• Chemical Name: 2-benzylacrylaMide
• CAS No.: 28769-51-9
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.203
• Mol file: 28769-51-9.mol

Synonyms:2-benzylprop-2-enamide

Chemical Property of 2-benzylacrylaMide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzylacrylaMide

There total 4 articles about 2-benzylacrylaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

α-benzylacrylonitrile (28769-48-4) → 2-benzylprop-2-enamide (28769-51-9)

Guidance literature:

With dihydrogen peroxide; sodium carbonate; In water; acetone; at 0 - 20 ℃;

DOI:10.1021/jacs.8b03704

Reference yield:

allylbenzene (300-57-2,57807-91-7) → 2-benzylprop-2-enamide (28769-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Ni(cod)2; N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene / toluene / 60 °C

2: 70 percent / TFA / 16 h / Heating

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; trifluoroacetic acid; 1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene; In toluene;

DOI:10.1021/ol063111x

Reference yield:

benzyl chloride (100-44-7) → 2-benzylprop-2-enamide (28769-51-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NaNH₂ / benzene

2: (heating)

3: H₂O₂ / ethanol; aq. NaOH

With dihydrogen peroxide; sodium amide; In sodium hydroxide; ethanol; benzene;

upstream raw materials:

α-benzylacrylonitrile

allylbenzene

benzyl chloride