FMOC-L-3-METHOXYPHENYLALANINE

Base Information

• Chemical Name: FMOC-L-3-METHOXYPHENYLALANINE
• CAS No.: 206060-40-4
• Molecular Formula: C₂₅H₂₃NO₅
• Molecular Weight: 417.461
• Hs Code.: 29225090
• Mol file: 206060-40-4.mol

Synonyms:Fmoc-3-Methoxy-L-Phenylalanine;Fmoc-3-methoxy-L-phenlyalanine;FMOC-L-3-METHOXYPHENYLALANINE;FMOC-3-METHOXY-L-PHE-OH;FMOC-L-3-MEO-PHE-OH;

Chemical Property of FMOC-L-3-METHOXYPHENYLALANINE

Chemical Property:

• PSA: 84.86000
• LogP: 4.62050
• Storage Temp.: Store at 0-5°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-3-methoxy-L-phenlyalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FMOC-L-3-METHOXYPHENYLALANINE

There total 3 articles about FMOC-L-3-METHOXYPHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H25NO5 → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-methoxyphenyl)propanoic acid (206060-40-4,917099-04-8)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 0 ℃; for 1h;

DOI:10.1021/ja512690x

Reference yield:

methyl (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(3-methoxyphenyl)propanoate → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-methoxyphenyl)propanoic acid (206060-40-4,917099-04-8)

Guidance literature:

Multi-step reaction with 3 steps

1: ethylenediamine / dichloromethane; methanol / 3 h / 40 °C

2: sodium hydrogencarbonate / water; 1,4-dioxane / 0 - 20 °C

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / 0 °C

With lithium hydroxide monohydrate; sodium hydrogencarbonate; ethylenediamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1021/ja512690x

Reference yield:

methyl (S)-2-amino-3-(3-methoxyphenyl)propanoate → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-methoxyphenyl)propanoic acid (206060-40-4,917099-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water; 1,4-dioxane / 0 - 20 °C

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / 0 °C

With lithium hydroxide monohydrate; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1021/ja512690x