(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen

Base Information

• Chemical Name: (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen
• CAS No.: 1332841-01-6
• Molecular Formula: C₁₄H₁₄O₃*C₁₅H₂₅NO₂
• Molecular Weight: 481.632
• Mol file: 1332841-01-6.mol

Synonyms:(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen

Chemical Property of (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen

There total 1 articles about (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3R)/(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol (175590-76-8,433936-13-1) + (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) → (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen (1332841-01-6) + (2R,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen (634921-25-8)

Guidance literature:

In acetonitrile; at 25 - 45 ℃; for 3h; Product distribution / selectivity;

Reference yield:

(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol S-naproxen (1332841-01-6) → (-)-(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol (454221-08-0,175590-76-8,433936-13-1)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; at 20 - 25 ℃; for 0.333333h; pH=9 - 10; Product distribution / selectivity;

upstream raw materials:

(2R,3R)/(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

Downstream raw materials:

(-)-(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol