FMOC-P-CARBOXY-PHE(OTBU)-OH

Base Information

Chemical Name:FMOC-P-CARBOXY-PHE(OTBU)-OH
CAS No.:183070-44-2
Molecular Formula:C29H29 N O6
Molecular Weight:487.552
Hs Code.:
Mol file:183070-44-2.mol

Synonyms:FMOC-L-PHE(4-COO-TBU);FMOC-O-T-BUTYL-P-CARBOXY-L-PHENYLALANINE;FMOC-PHE(4-COOTBU)-OH;FMOC-P-CARBOXY-PHENYLALANINE(OTBU)-OH;FMOC-P-CARBOXY-PHE(OTBU)-OH;FMOC-CPH(P-OTBU)-OH;FMOC-(4-CARBOXY-T-BUTYL)-L-PHENYLALANINE;FMOC-(4-T-BUTYLOXYCARBONYL)-L-PHENYLALANINE

Suppliers and Price of FMOC-P-CARBOXY-PHE(OTBU)-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fmoc-p-carboxy-phe(OtBu)-OH
1g
$ 495.00

Oakwood
Fmoc-p-carboxy-phe(OtBu)-OH
250mg
$ 220.00

Oakwood
Fmoc-p-carboxy-phe(OtBu)-OH
1g
$ 450.00

Medical Isotopes, Inc.
Fmoc-Phe(4-COOtBu)-OH
1 g
$ 600.00

Medical Isotopes, Inc.
Fmoc-Phe(4-COOtBu)-OH
5 g
$ 1150.00

Crysdot
Fmoc-P-carboxy-Phe(OtBu)-OH 97%
1g
$ 371.00

Chem-Impex
Fmoc-(4-tert-butyloxycarbonyl)-L-phenylalanine,98%(HPLC) 98%(HPLC)
5G
$ 1114.40

Chem-Impex
Fmoc-(4-tert-butyloxycarbonyl)-L-phenylalanine,98%(HPLC) 98%(HPLC)
1G
$ 280.00

Chem-Impex
Fmoc-(4-tert-butyloxycarbonyl)-L-phenylalanine,98%(HPLC) 98%(HPLC)
100MG
$ 72.80

Chem-Impex
Fmoc-(4--butyloxycarbonyl)-L-phenylalanine ≥ 98% (HPLC)
250MG
$ 125.00

Total 23 raw suppliers

Chemical Property of FMOC-P-CARBOXY-PHE(OTBU)-OH

Chemical Property:

Boiling Point:684.6±55.0 °C(Predicted)
PKA:3.67±0.10(Predicted)
PSA：101.93000
Density:1.247±0.06 g/cm3(Predicted)
LogP:5.56720
Storage Temp.:-15°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-p-carboxy-phe(OtBu)-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Fmoc-p-carboxy-phe(OtBu)-OH is used in Fmoc-based solid-phase peptide synthesis.

Technology Process of FMOC-P-CARBOXY-PHE(OTBU)-OH

There total 4 articles about FMOC-P-CARBOXY-PHE(OTBU)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5513-40-6
benzyl N-carbobenzyloxy-L-tyrosine

: 183070-44-2
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxycarbonyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / 2,6-lutidine / CH₂Cl₂ / -40 °C

2: 89 percent / AcOK, 1,1'-bis(diphenylphosphino)ferrocene / Pd(OAc)2 / dimethylformamide / 3 h / 60 °C

3: 80 percent / BF₃*Et₂O / CH₂Cl₂; cyclohexane / 3 h / Ambient temperature

4: H₂ / Pd/C

5: Na₂CO₃ / H₂O; acetone / 2 h / Ambient temperature

With 2,6-dimethylpyridine; 1,1'-bis-(diphenylphosphino)ferrocene; boron trifluoride diethyl etherate; hydrogen; potassium acetate; sodium carbonate; palladium diacetate; palladium on activated charcoal; In dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(96)01490-6

Reference yield:

: 183070-43-1
4-((S)-2-Benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-benzoic acid tert-butyl ester

: 183070-44-2
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxycarbonyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C

2: Na₂CO₃ / H₂O; acetone / 2 h / Ambient temperature

With hydrogen; sodium carbonate; palladium on activated charcoal; In water; acetone;
DOI:10.1016/S0040-4039(96)01490-6

Reference yield:

: 183070-42-0
4-((S)-2-Benzyloxycarbonyl-2-benzyloxycarbonylamino-ethyl)-benzoic acid

: 183070-44-2
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxycarbonyl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / BF₃*Et₂O / CH₂Cl₂; cyclohexane / 3 h / Ambient temperature

2: H₂ / Pd/C

3: Na₂CO₃ / H₂O; acetone / 2 h / Ambient temperature

With boron trifluoride diethyl etherate; hydrogen; sodium carbonate; palladium on activated charcoal; In dichloromethane; cyclohexane; water; acetone;
DOI:10.1016/S0040-4039(96)01490-6