1-(4-Chlorophenyl)-3-piperidin-4-ylurea

Base Information

Chemical Name:1-(4-Chlorophenyl)-3-piperidin-4-ylurea
CAS No.:503464-80-0
Molecular Formula:C₁₂H₁₆ClN₃O
Molecular Weight:253.732
Hs Code.:
DSSTox Substance ID:DTXSID101280844

Synonyms:1-(4-chlorophenyl)-3-piperidin-4-ylurea;503464-80-0;SCHEMBL16825746;DTXSID101280844;AKOS004119606;N-(4-Chlorophenyl)-N'-4-piperidinylurea;Z390180720

Suppliers and Price of 1-(4-Chlorophenyl)-3-piperidin-4-ylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-Chlorophenyl)-3-piperidin-4-ylurea

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:253.0981898
Heavy Atom Count:17
Complexity:248

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCCC1NC(=O)NC2=CC=C(C=C2)Cl

Technology Process of 1-(4-Chlorophenyl)-3-piperidin-4-ylurea

There total 3 articles about 1-(4-Chlorophenyl)-3-piperidin-4-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 4-(3-(4-chlorophenyl)ureido)piperidine-1-carboxylate

: 503464-80-0
C₁₂H₁₆ClN₃O

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2018.12.064

Reference yield:

: 106-47-8
4-chloro-aniline

: 503464-80-0
C₁₂H₁₆ClN₃O

Guidance literature:: Multi-step reaction with 2 steps

1: bis(trichloromethyl) carbonate; triethylamine / acetonitrile / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With bis(trichloromethyl) carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2018.12.064

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 503464-80-0
C₁₂H₁₆ClN₃O

Guidance literature:: Multi-step reaction with 2 steps

1: bis(trichloromethyl) carbonate; triethylamine / acetonitrile / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With bis(trichloromethyl) carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2018.12.064