(2S,2'S,2S,4S)-N-{2-[2'-(tert-butoxycarbonyl)amino-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyl}-2-(4-methoxybutoxy)-benzamide

Base Information

• Chemical Name: (2S,2'S,2S,4S)-N-{2-[2'-(tert-butoxycarbonyl)amino-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyl}-2-(4-methoxybutoxy)-benzamide
• CAS No.: 179994-18-4
• Molecular Formula: C₃₁H₅₀N₂O₇
• Molecular Weight: 562.747

Synonyms:(2S,2'S,2S,4S)-N-{2-[2'-(tert-butoxycarbonyl)amino-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyl}-2-(4-methoxybutoxy)-benzamide

Chemical Property of (2S,2'S,2S,4S)-N-{2-[2'-(tert-butoxycarbonyl)amino-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyl}-2-(4-methoxybutoxy)-benzamide

Chemical Property:

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Technology Process of (2S,2'S,2S,4S)-N-{2-[2'-(tert-butoxycarbonyl)amino-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyl}-2-(4-methoxybutoxy)-benzamide

There total 1 articles about (2S,2'S,2S,4S)-N-{2-[2'-(tert-butoxycarbonyl)amino-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyl}-2-(4-methoxybutoxy)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxybutoxy)-benzoic acid (179993-33-0) + (3S,5S,1'S,3'S)-5-[3'-aminomethyl-1'-(tert-butoxycarbonyl)amino-4'-methylpentyl]-3-isopropyl-dihydrofuran-2-one → (2S,2'S,2S,4S)-N-{2-[2'-(tert-butoxycarbonyl)amino-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyl}-2-(4-methoxybutoxy)-benzamide (179994-18-4)

Guidance literature:

With dmap; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

(2S,2'S,2S,4S)-N-{2-[2'-(tert-butoxycarbonyl)amino-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyl}-2-(4-methoxybutoxy)-benzamide (179994-18-4) → (2S,4S,5S,7S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-2-isopropyl-7-{[2-(4-methoxybutoxy)-benzoylamino]-methyl}-8-methyl-nonanoic acid (179995-54-1)

Guidance literature:

With lithium hydroxide; water; In 1,2-dimethoxyethane; at 20 ℃; for 1h;

Reference yield:

2-hydroxypyridin (142-08-5) + (2S,2'S,2S,4S)-N-{2-[2'-(tert-butoxycarbonyl)amino-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyl}-2-(4-methoxybutoxy)-benzamide (179994-18-4) → (2S,4S,5S,7S)-N-{7-[2-(4-acetylpiperidin-1-yl)-ethylcarbamoyl]-4-(tert-butoxycarbonyl)amino-5-hydroxy-2-isopropyl-8-methyl-nonyl}-2-(4-methoxybutoxy)-benzamide (179995-79-0)

Guidance literature:

With triethylamine; at 80 ℃; for 19h;

upstream raw materials:

2-(4-methoxybutoxy)-benzoic acid

Downstream raw materials:

(2S,4S,5S,7S)-N-{7-[2-(4-acetylpiperidin-1-yl)-ethylcarbamoyl]-4-(tert-butoxycarbonyl)amino-5-hydroxy-2-isopropyl-8-methyl-nonyl}-2-(4-methoxybutoxy)-benzamide

(2S,4S,5S,7S)-N-[4-(tert-butoxycarbonyl)amino-5-hydroxy-2-isopropyl-8-methyl-7-(3-morpholin-4-ylpropylcarbamoyl)-nonyl]-2-(4-methoxybutoxy)-benzamide

(2S,4S,5S,7S)-5-(tert-butoxycarbonyl)amino-4-hydroxy-2-isopropyl-7-{[2-(4-methoxybutoxy)-benzoylamino]-methyl}-8-methyl-nonanoic acid

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