Tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: Tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate
• CAS No.: 411238-88-5
• Molecular Formula: C10H19 N3 O3
• Molecular Weight: 229.279
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80404986
• Mol file: 411238-88-5.mol

Synonyms:411238-88-5;Tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate;3-Hydrazinocarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester;1-Boc-3-hydrazinocarbonylpyrrolidine;SCHEMBL316087;DTXSID80404986;HFMHEXPZANOFSL-UHFFFAOYSA-N;AMY35503;MFCD03791258;AKOS015838322;1-Boc-3-(hydrazinecarbonyl)pyrrolidine;PB20857;SB20823;SB20824;AS-50453;CS-0048365;FT-0677583;EN300-212930;P10275;A825446;1-BOC-PYRROLIDINE-3-CARBOXYLIC ACID HYDRAZIDE;Tert-butyl3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate;3-Hydrazinocarbonyl-pyrrolidine-1-carboxylicacidtert-butylester;TERT-BUTYL 3-(HYDRAZINOCARBONYL)PYRROLIDINE-1-CARBOXYLATE;1,3-Pyrrolidinedicarboxylicacid,1-(1,1-dimethylethyl)ester,3-hydrazide;3-Hydrazinocarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester, AldrichCPR;tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate

Chemical Property of Tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

Chemical Property:

• Vapor Pressure: 1.8E-06mmHg at 25°C
• Boiling Point: 395.8°Cat760mmHg
• PKA: 13.04±0.20(Predicted)
• Flash Point: 193.1°C
• PSA: 84.66000
• Density: 1.18g/cm³
• LogP: 1.26240
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 229.14264148
• Heavy Atom Count: 16
• Complexity: 286

Purity/Quality:

97% ^*data from raw suppliers

3-Hydrazinocarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(C1)C(=O)NN

Technology Process of Tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

There total 1 articles about Tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate (122684-33-7) → tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate (411238-88-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 3h;

Reference yield:

(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid (1174020-25-7,2064219-13-0) + tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate (411238-88-5) → tert-butyl 3-[(2-{[(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}hydrazinyl)carbonyl]pyrrolidine-1-carboxylate (1452467-45-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

tert-butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate (411238-88-5) + ethyl benzimidate hydrochloride (5333-86-8) → tert-butyl 3-(5-phenyl-4H-1,2,4-triazol-3-yl)pyrrolidine-1-carboxylate

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In isopropyl alcohol; at 130 ℃; for 0.416667h; Microwave irradiation;

upstream raw materials:

methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate

Downstream raw materials:

tert-butyl 3-[(2-{[(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}hydrazinyl)carbonyl]pyrrolidine-1-carboxylate

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