4-(3,4-dinitro-phenoxy)-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 4-(3,4-dinitro-phenoxy)-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine
• CAS No.: 952490-58-3
• Molecular Formula: C₁₂H₇N₅O₅
• Molecular Weight: 301.218
• Mol file: 952490-58-3.mol

Synonyms:4-(3,4-dinitro-phenoxy)-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine

Chemical Property of 4-(3,4-dinitro-phenoxy)-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,4-dinitro-phenoxy)-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine

There total 1 articles about 4-(3,4-dinitro-phenoxy)-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

3,4-dinitophenol (577-71-9) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 4-(3,4-dinitro-phenoxy)-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine (952490-58-3)

Guidance literature:

With TEA; trifluoroacetic acid; at 150 ℃; for 2h;

DOI:10.1021/jm070034i

Reference yield:

4-(3,4-dinitro-phenoxy)-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine (952490-58-3) → 4-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)benzene-1,2-diamine (952490-48-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; at 20 ℃; for 18h; under 760.051 Torr;

DOI:10.1021/jm070034i

Reference yield:

4-(3,4-dinitro-phenoxy)-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine (952490-58-3) → C25H25ClN8O

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂ / Pd/C / methanol; ethyl acetate / 18 h / 20 °C / 760.05 Torr

2.1: acetonitrile / 18 h / 20 °C

2.2: 15 mg / 1-(3-dimethyl-aminopropyl)-3-ethylcarbodiimide / acetonitrile / 3 h / 80 °C

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; acetonitrile;

DOI:10.1021/jm070034i

upstream raw materials:

3,4-dinitophenol

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

4-(7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)benzene-1,2-diamine