5-{4-[(E)-3-(5-Methyl-2-phenyl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione

Base Information

Chemical Name:5-{4-[(E)-3-(5-Methyl-2-phenyl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione
CAS No.:141200-22-8
Molecular Formula:C₂₃H₁₈N₂O₄S
Molecular Weight:418.473
Hs Code.:

Synonyms:5-{4-[(E)-3-(5-Methyl-2-phenyl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione

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Chemical Property of 5-{4-[(E)-3-(5-Methyl-2-phenyl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione

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Technology Process of 5-{4-[(E)-3-(5-Methyl-2-phenyl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione

There total 5 articles about 5-{4-[(E)-3-(5-Methyl-2-phenyl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 5-methyl-3-oxo-2-phenyloxazole-4-carboxylate hydrochloride

: 141200-22-8
5-{4-[(E)-3-(5-Methyl-2-phenyl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / H₂ / 10percent Pd/C / ethanol; methanol / 3 h / 2585.7 Torr

2: 84 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

3: 70 percent / pyridinium dichromate / CH₂Cl₂ / 7 h

4: MeONa / ethanol

With lithium aluminium tetrahydride; dipyridinium dichromate; hydrogen; sodium methylate; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm00088a022

Reference yield:

: 70502-03-3
[5-methyl-2-phenyl-1,3-oxazol-4-yl]methanol

: 141200-22-8
5-{4-[(E)-3-(5-Methyl-2-phenyl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / pyridinium dichromate / CH₂Cl₂ / 7 h

2: MeONa / ethanol

With dipyridinium dichromate; sodium methylate; In ethanol; dichloromethane;
DOI:10.1021/jm00088a022

Reference yield:

: 61151-96-0
ethyl 5-methyl-2-phenyloxazole-4-carboxylate

: 141200-22-8
5-{4-[(E)-3-(5-Methyl-2-phenyl-oxazol-4-yl)-acryloyl]-benzyl}-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

2: 70 percent / pyridinium dichromate / CH₂Cl₂ / 7 h

3: MeONa / ethanol

With lithium aluminium tetrahydride; dipyridinium dichromate; sodium methylate; In diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm00088a022