(2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis-(2-trimethylsilanylethynyl-benzyloxy)-hexanedioic acid bis-[((1S,2R)-2-hydroxy-indan-1-yl)-amide]

Base Information

Chemical Name:(2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis-(2-trimethylsilanylethynyl-benzyloxy)-hexanedioic acid bis-[((1S,2R)-2-hydroxy-indan-1-yl)-amide]
CAS No.:906071-60-1
Molecular Formula:C₄₈H₅₆N₂O₈Si₂
Molecular Weight:845.152
Hs Code.:

Synonyms:(2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis-(2-trimethylsilanylethynyl-benzyloxy)-hexanedioic acid bis-[((1S,2R)-2-hydroxy-indan-1-yl)-amide]

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Chemical Property of (2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis-(2-trimethylsilanylethynyl-benzyloxy)-hexanedioic acid bis-[((1S,2R)-2-hydroxy-indan-1-yl)-amide]

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Technology Process of (2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis-(2-trimethylsilanylethynyl-benzyloxy)-hexanedioic acid bis-[((1S,2R)-2-hydroxy-indan-1-yl)-amide]

There total 3 articles about (2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis-(2-trimethylsilanylethynyl-benzyloxy)-hexanedioic acid bis-[((1S,2R)-2-hydroxy-indan-1-yl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 890653-17-5
N₁,N₆-bis[(1S,2R)-2-hydroxy-1-indanyl]-(2R,3R,4R,5R)-2,5-bis(2-iodobenzyloxy)-3,4-dihydroxyhexane-1,6-diamide

: 1066-54-2
trimethylsilylacetylene

: 906071-60-1
(2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis-(2-trimethylsilanylethynyl-benzyloxy)-hexanedioic acid bis-[((1S,2R)-2-hydroxy-indan-1-yl)-amide]

Guidance literature:: With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 120 ℃; for 0.25h; microwave irradiation;
DOI:10.1016/j.bmc.2006.03.045

Reference yield:

: (3R,3aR,6R,6aR)-3,6-Bis-(2-iodo-benzyloxy)-tetrahydro-furo[3,2-b]furan-2,5-dione

: 906071-60-1
(2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis-(2-trimethylsilanylethynyl-benzyloxy)-hexanedioic acid bis-[((1S,2R)-2-hydroxy-indan-1-yl)-amide]

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / 1,2-dichloro-ethane / 5 h / 50 °C

2: 44 percent / diethylamine; CuI / Pd(PPh₃)2Cl₂ / acetonitrile / 0.25 h / 120 °C / microwave irradiation

With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dichloro-ethane; acetonitrile; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2006.03.045

Reference yield:

: 7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8
(1S,2R)-1-amino-2-indanol

: 906071-60-1
(2R,3R,4R,5R)-3,4-Dihydroxy-2,5-bis-(2-trimethylsilanylethynyl-benzyloxy)-hexanedioic acid bis-[((1S,2R)-2-hydroxy-indan-1-yl)-amide]

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / 1,2-dichloro-ethane / 5 h / 50 °C

2: 44 percent / diethylamine; CuI / Pd(PPh₃)2Cl₂ / acetonitrile / 0.25 h / 120 °C / microwave irradiation

With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dichloro-ethane; acetonitrile; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2006.03.045