5-[(2-Methylphenyl)amino]-5-oxopentanoic acid

Base Information

Chemical Name:5-[(2-Methylphenyl)amino]-5-oxopentanoic acid
CAS No.:78648-34-7
Molecular Formula:C₁₂H₁₅NO₃
Molecular Weight:221.256
Hs Code.:
European Community (EC) Number:666-050-6

Synonyms:78648-34-7;5-[(2-methylphenyl)amino]-5-oxopentanoic acid;5-(2-methylanilino)-5-oxopentanoic acid;4-[(2-methylphenyl)carbamoyl]butanoic Acid;2'-methylglutaranilic acid;CBKinase1_002385;CBKinase1_014785;Cambridge id 7136882;Oprea1_169590;SCHEMBL7822083;MFCD00029861;STK267886;AKOS000987320;CCG-294450;EN300-10189403;SR-01000400726;SR-01000400726-1;BRD-K18206853-001-01-4;Z56754004

Suppliers and Price of 5-[(2-Methylphenyl)amino]-5-oxopentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 5-[(2-Methylphenyl)amino]-5-oxopentanoic acid

Chemical Property:

XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:221.10519334
Heavy Atom Count:16
Complexity:253

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC=C1NC(=O)CCCC(=O)O

Technology Process of 5-[(2-Methylphenyl)amino]-5-oxopentanoic acid

There total 5 articles about 5-[(2-Methylphenyl)amino]-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 343945-28-8
N-(2-methylphenyl)-2-piperidone

: 78648-36-9
N-(2-Carboxyphenyl)-glutaramidsaeure

: 78648-34-7
N-(2-Tolyl)-glutaramidsaeure

: 78648-35-8
2-(2-oxopiperidin-1-yl)benzoic acid

Guidance literature:: With potassium permanganate; sodium carbonate; In water; for 3h; Heating;
DOI:10.1002/ardp.19813140610

Reference yield:

: 108-55-4
glutaric anhydride,

: 95-53-4
o-toluidine

: 78648-34-7
N-(2-Tolyl)-glutaramidsaeure

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 6h;
DOI:10.1016/j.bioorg.2021.104872

Reference yield:

: 4509-90-4
5-bromovaleroyl chloride

: 78648-34-7
N-(2-Tolyl)-glutaramidsaeure

Guidance literature:: Multi-step reaction with 3 steps

1: 74.8 percent

2: 70.1 percent / NaH-DMSO / benzene

3: 20 percent / KMnO₄, Na₂CO₃ / H₂O / 3 h / Heating

With potassium permanganate; sodium hydride; sodium carbonate; dimethyl sulfoxide; In water; benzene;
DOI:10.1002/ardp.19813140610