5-(5-amino-6-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyrazin-2-yl)pyridine-2-carboxamide

Base Information

Chemical Name:5-(5-amino-6-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyrazin-2-yl)pyridine-2-carboxamide
CAS No.:1346815-72-2
Molecular Formula:C₂₀H₁₇FN₈O₂
Molecular Weight:420.406
Hs Code.:

Synonyms:5-(5-amino-6-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyrazin-2-yl)pyridine-2-carboxamide

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Chemical Property of 5-(5-amino-6-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyrazin-2-yl)pyridine-2-carboxamide

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Technology Process of 5-(5-amino-6-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyrazin-2-yl)pyridine-2-carboxamide

There total 4 articles about 5-(5-amino-6-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyrazin-2-yl)pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.6%

: 179117-44-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

: 1346819-45-1
5-bromo-3-[(R)-1-(5-fluoro-2-[1,2,3]triazol-2-ylphenyl)ethoxy]pyrazin-2-ylamine

: 1346815-72-2
5-(5-amino-6-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyrazin-2-yl)pyridine-2-carboxamide

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1979-36-8
2',5'-difluoroacetophenone

: 1346815-72-2
5-(5-amino-6-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyrazin-2-yl)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 3 h / 140 °C / Inert atmosphere

2.1: B-chlorodiisopinocampheylborane / tetrahydrofuran / 4.67 h / -30 - 10 °C

2.2: 20 °C / Reflux

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

3.2: 0 °C / Reflux

4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1 h / 120 °C / Microwave irradiation

With sodium hydride; sodium carbonate; potassium carbonate; B-chlorodiisopinocampheylborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water; mineral oil;

Reference yield:

: 1346817-32-0
1-[5-fluoro-2-(1,2,3-triazol-2-yl)phenyl]ethanone

: 1346815-72-2
5-(5-amino-6-{(1R)-1-[5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]ethoxy}pyrazin-2-yl)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: B-chlorodiisopinocampheylborane / tetrahydrofuran / 4.67 h / -30 - 10 °C

1.2: 20 °C / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C / Inert atmosphere

2.2: 0 °C / Reflux

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1 h / 120 °C / Microwave irradiation

With sodium hydride; sodium carbonate; B-chlorodiisopinocampheylborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; water; mineral oil;