7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester

Base Information

Chemical Name:7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester
CAS No.:260391-46-6
Molecular Formula:C₂₄H₂₈N₂O₈S
Molecular Weight:504.561
Hs Code.:

7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1<i>H</i>,5<i>H</i>-benzo[<i>e</i>]pyrrolo[1,2-<i>a</i>][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester

Synonyms:7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester

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Chemical Property of 7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester

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Technology Process of 7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester

There total 10 articles about 7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 260391-48-8
7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-phenylsulfanyl-ethyl ester

: 260391-46-6
7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃;
DOI:10.1016/S0960-894X(02)00150-6

Reference yield:

: 71461-30-8
(S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester

: 260391-46-6
7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / methanol / 60 °C

2: H₂ / 10 percent Pd/C / ethanol

3: 51 percent / TBTU; DIPEA / dimethylformamide

4: H₂ / 10 percent Pd/C / ethanol

5: pyridine / CH₂Cl₂ / 0 °C

6: (CH₃CN)2PdCl₂ / acetone

With pyridine; dichloro bis(acetonitrile) palladium(II); thionyl chloride; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; 10% palladium on active carbon; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0960-894X(02)00150-6

Reference yield:

: 6216-63-3
N-Cbz-Prolinol

: 260391-46-6
7,8,11-trimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carboxylic acid 2-benzenesulfonyl-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: SO₃-pyridine; Et₃N / dimethylsulfoxide; CH₂Cl₂ / -10 °C

2: SOCl₂ / methanol / 60 °C

3: H₂ / 10 percent Pd/C / ethanol

4: 51 percent / TBTU; DIPEA / dimethylformamide

5: H₂ / 10 percent Pd/C / ethanol

6: pyridine / CH₂Cl₂ / 0 °C

7: (CH₃CN)2PdCl₂ / acetone

With pyridine; dichloro bis(acetonitrile) palladium(II); thionyl chloride; pyridine-SO₃ complex; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; 10% palladium on active carbon; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0960-894X(02)00150-6