2-ACETOXY-5-NITROBENZYL CHLORIDE

Base Information

• Chemical Name: 2-ACETOXY-5-NITROBENZYL CHLORIDE
• CAS No.: 5174-32-3
• Molecular Formula: C₉H₈ClNO₄
• Molecular Weight: 229.62
• Hs Code.: 2915390090
• Mol file: 5174-32-3.mol

Synonyms:o-Cresol, a-chloro-4-nitro-, acetate (7CI);o-Cresol, a-chloro-4-nitro-, acetate (ester)(8CI); 2-Acetoxy-5-nitrobenzyl chloride

Chemical Property of 2-ACETOXY-5-NITROBENZYL CHLORIDE

Chemical Property:

• Vapor Pressure: 4.82E-06mmHg at 25°C
• Melting Point: 83 °C(Solv: ethanol (64-17-5))
• Boiling Point: 382.2°C at 760 mmHg
• Flash Point: 184.9°C
• PSA: 72.12000
• Density: 1.378g/cm³
• LogP: 2.78210

Purity/Quality:

99%, ^*data from raw suppliers

2-ACETOXY-5-NITROBENZYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ACETOXY-5-NITROBENZYL CHLORIDE

There total 2 articles about 2-ACETOXY-5-NITROBENZYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-5-nitrobenzyl chloride (2973-19-5) + acetic anhydride (108-24-7) → 2-acetoxy-5-nitrobenzylchloride (5174-32-3)

Guidance literature:

With sulfuric acid;

Reference yield:

→ 2-acetoxy-5-nitrobenzylchloride (5174-32-3)

Guidance literature:

/BRN= 868797/, CH3COCl;

Reference yield:

2-acetoxy-5-nitrobenzylchloride (5174-32-3) → 2-amino-3-(2,5-dihydroxyphenyl)propanoic acid (26122-90-7,582-32-1)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) Mg, EtOH, (ii) /BRN= 2217433/

2: Al-Hg / ethanol

3: K₂Cr₂O₇, aq. H₂SO₄

4: H₂ / Pd-C

With potassium dichromate; aluminium amalgam; sulfuric acid; hydrogen; palladium on activated charcoal; In ethanol;

upstream raw materials:

2-hydroxy-5-nitrobenzyl chloride

acetic anhydride

Downstream raw materials:

acetylamino-(2-hydroxy-5-nitro-benzyl)-malonic acid diethyl ester

2-amino-3-(2,5-dihydroxyphenyl)propanoic acid

2-Acetamino-3-<1,4>benzochinolyl-propionsaeure-aethylester

Acetamino-<(1,4)benzochinonyl-methyl>-malonsaeure-diaethylester