2'-(tert-butyldimethylsiloxy)-7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel

Base Information

• Chemical Name: 2'-(tert-butyldimethylsiloxy)-7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel
• CAS No.: 1151988-97-4
• Molecular Formula: C₆₆H₇₄N₂O₁₆S₂Si
• Molecular Weight: 1243.53
• Mol file: 1151988-97-4.mol

Synonyms:2'-(tert-butyldimethylsiloxy)-7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel

Chemical Property of 2'-(tert-butyldimethylsiloxy)-7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-(tert-butyldimethylsiloxy)-7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel

There total 1 articles about 2'-(tert-butyldimethylsiloxy)-7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C60H68N2O18Si (1096541-05-7) + (4-(pyridin-2-yldisulfanyl)phenyl)methanol (126049-37-4) → 2'-(tert-butyldimethylsiloxy)-7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel (1151988-97-4)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.bioconjchem.6b00405

Reference yield: 92.0%

2'-(tert-butyldimethylsiloxy)-7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel (1151988-97-4) → 7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel (1151989-01-3)

Guidance literature:

With pyridine hydrogenfluoride; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.bioconjchem.6b00405

upstream raw materials:

C₆₀H₆₈N₂O₁₈Si

(4-(pyridin-2-yldisulfanyl)phenyl)methanol

Downstream raw materials:

7-((4-(pyridin-2-yldisulfanyl)benzyloxy)carbonyloxy)paclitaxel