N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

Base Information

Chemical Name:N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine
CAS No.:214750-88-6
Molecular Formula:C₄₅H₆₃N₇O₆
Molecular Weight:798.039
Hs Code.:

N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

Synonyms:N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

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Chemical Property of N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

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Technology Process of N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

There total 6 articles about N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 31265-81-3
11-(3-Chloro-1-oxopropyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

: 214750-85-3
N1-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

: 214750-88-6
N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

Guidance literature:: With triethylamine; potassium iodide; In dichloromethane;
DOI:10.1021/jm981038d

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 214750-88-6
N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) ethyl chlorocarbomate, Et₃N / 1.) dioxane, 30 min, 2.) dioxane, RT, overnight

2: 75 percent / H₂ / 10 percent Pd/C / methanol / 0.75 h / 775.72 Torr / Ambient temperature

3: 1.) ethyl chlorocarbomate, Et₃N / 1.) dioxane, 30 min, 2.) dioxane, RT, overnight

4: 96 percent / 6N aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

5: 43 percent / Et₃N, KI / CH₂Cl₂

With hydrogenchloride; hydrogen; chloroformic acid ethyl ester; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm981038d

Reference yield:

: N'-<(benzyloxy)carbonyl>-N,N'-dimethyl-1,8-octanediamine

: 214750-88-6
N1-<<(5,11-dihydro-6-oxo-6H-pyrido<2,3-b><1,4>benzodiazepin-11-yl)carbonyl>ethyl>-N22-<(benzyloxy)carbonyl>-7,16-dimethyl-6,17-dioxo-7,16-diaza-1,22-docosanediamine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) ethyl chlorocarbomate, Et₃N / 1.) dioxane, 30 min, 2.) dioxane, RT, overnight

2: 75 percent / H₂ / 10 percent Pd/C / methanol / 0.75 h / 775.72 Torr / Ambient temperature

3: 1.) ethyl chlorocarbomate, Et₃N / 1.) dioxane, 30 min, 2.) dioxane, RT, overnight

4: 96 percent / 6N aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

5: 43 percent / Et₃N, KI / CH₂Cl₂

With hydrogenchloride; hydrogen; chloroformic acid ethyl ester; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm981038d