(S)-N-((R)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide

Base Information

Chemical Name:(S)-N-((R)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide
CAS No.:1402599-18-1
Molecular Formula:C₂₇H₂₆ClF₃N₂O₂S₂
Molecular Weight:567.096
Hs Code.:

Synonyms:(S)-N-((R)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide

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Chemical Property of (S)-N-((R)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide

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Technology Process of (S)-N-((R)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide

There total 10 articles about (S)-N-((R)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402598-94-0
N-((S,1E)-(2-chlorophenyl)methylidene)-2-methyl-2-propanesulfinamide

: 1402599-16-9
(2R)-2-(2-(1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1-trifluoro-2-propanol

: 1402599-18-1
(S)-N-((R)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide

Guidance literature:: (2R)-2-(2-(1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1-trifluoro-2-propanol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

N-((S,1E)-(2-chlorophenyl)methylidene)-2-methyl-2-propanesulfinamide; In tetrahydrofuran; hexane; at -78 ℃;

Reference yield:

: 1402598-94-0
N-((S,1E)-(2-chlorophenyl)methylidene)-2-methyl-2-propanesulfinamide

: 1402599-16-9
(2R)-2-(2-(1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1-trifluoro-2-propanol

: 1402599-18-1
(S)-N-((R)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide

: (S)-N-((S)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide

Guidance literature:: (2R)-2-(2-(1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1-trifluoro-2-propanol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

N-((S,1E)-(2-chlorophenyl)methylidene)-2-methyl-2-propanesulfinamide; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

Reference yield:

: 1402599-08-9
2-(2-chloro-4-pyridinyl)-1,1,1-trifluoro-2-propanol

: 1402599-18-1
(S)-N-((R)-(2-chlorophenyl)(7-(4-((1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Chiralcel^.(R). OJ- H column / isopropyl alcohol; hexane; carbon dioxide / Resolution of racemate

2.1: sodium carbonate; XPhos / bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 2 h / 80 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C

3.2: -78 °C

With n-butyllithium; sodium carbonate; XPhos; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; 1,4-dioxane; hexane; carbon dioxide; water; isopropyl alcohol;