(R)-3-Hydroxy-5-tert-butyl-alpha-aminoisoxazole-4-propanoic acid

Base Information

• Chemical Name: (R)-3-Hydroxy-5-tert-butyl-alpha-aminoisoxazole-4-propanoic acid
• CAS No.: 83654-14-2
• Molecular Formula: C10H16N2O4
• Molecular Weight: 228.25
• DSSTox Substance ID: DTXSID401017549
• Nikkaji Number: J621.629C
• Mol file: 83654-14-2.mol

Synonyms:83654-14-2;(2R)-2-amino-3-(5-tert-butyl-3-oxo-1,2-oxazol-4-yl)propanoic acid;(R)-ATPA;ATPA-S;(R)-3-Hydroxy-5-tert-butyl-alpha-aminoisoxazole-4-propanoic acid;BDBM85744;DTXSID401017549;PD132961;(S)-alpha-Amino-3-hydroxy-5-t-butyl-4-isoxazolepropionic acid

Chemical Property of (R)-3-Hydroxy-5-tert-butyl-alpha-aminoisoxazole-4-propanoic acid

Chemical Property:

• PSA: 109.58000
• LogP: 1.33240
• Storage Temp.: Refrigerator
• Solubility.: DMSO: 10 mg/mL
• XLogP3: -1.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 228.11100700
• Heavy Atom Count: 16
• Complexity: 354

Purity/Quality:

99% ^*data from raw suppliers

ATPA solid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=C(C(=O)NO1)CC(C(=O)O)N
• Isomeric SMILES: CC(C)(C)C1=C(C(=O)NO1)C[C@H](C(=O)O)N
• Uses: (R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.