(4-(4-chlorobenzyl)-2-amino-5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Base Information

Chemical Name:(4-(4-chlorobenzyl)-2-amino-5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone
CAS No.:1265048-27-8
Molecular Formula:C₂₇H₂₄ClNO₄S
Molecular Weight:494.011
Hs Code.:

Synonyms:(4-(4-chlorobenzyl)-2-amino-5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

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Chemical Property of (4-(4-chlorobenzyl)-2-amino-5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

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Technology Process of (4-(4-chlorobenzyl)-2-amino-5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

There total 7 articles about (4-(4-chlorobenzyl)-2-amino-5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1265049-17-9
2-[5-phenyl-4-(4-chlorobenzyl)-3-(3,4,5-trimethoxybenzoyl)-2-thienyl]-1H-isoindole-1,3(2H)-dione

: 1265048-27-8
(4-(4-chlorobenzyl)-2-amino-5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: With hydrazine hydrate; In ethanol; for 2h; Inert atmosphere; Reflux;
DOI:10.2174/157340610793563974

Reference yield:

: 901118-42-1
(2-amino-4-methylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

: 1265048-27-8
(4-(4-chlorobenzyl)-2-amino-5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / 18 h / Reflux; Inert atmosphere

2: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 6 h / Inert atmosphere; Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 18 h / 120 °C / Inert atmosphere

4: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / Inert atmosphere; Reflux

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 18 h / 120 °C / Inert atmosphere

6: hydrazine hydrate / ethanol / 2 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; hydrazine hydrate; acetic acid; dibenzoyl peroxide; In tetrachloromethane; ethanol; toluene; benzene; 3: Suzuki coupling / 5: Suzuki coupling;
DOI:10.2174/157340610793563974

Reference yield:

: 901118-50-1
2-[4-methyl-3-(3,4,5-trimethoxybenzoyl)-2-thienyl]-1H-isoindole-1,3(2H)-dione

: 1265048-27-8
(4-(4-chlorobenzyl)-2-amino-5-phenylthiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / benzene / 6 h / Inert atmosphere; Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 18 h / 120 °C / Inert atmosphere

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / Inert atmosphere; Reflux

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 18 h / 120 °C / Inert atmosphere

5: hydrazine hydrate / ethanol / 2 h / Inert atmosphere; Reflux

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; hydrazine hydrate; dibenzoyl peroxide; In tetrachloromethane; ethanol; toluene; benzene; 2: Suzuki coupling / 4: Suzuki coupling;
DOI:10.2174/157340610793563974