N-{2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N'-(4-chlorophenyl)urea

Base Information

Chemical Name:N-{2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N'-(4-chlorophenyl)urea
CAS No.:1222386-18-6
Molecular Formula:C₂₇H₃₄ClN₅O₄
Molecular Weight:528.051
Hs Code.:

Synonyms:N-{2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N'-(4-chlorophenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N'-(4-chlorophenyl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-{2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N'-(4-chlorophenyl)urea

There total 7 articles about N-{2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N'-(4-chlorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 163618-12-0
3-amino-2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 104-12-1
p-chlorphenylisocyanate

: 1222386-18-6
N-{2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N'-(4-chlorophenyl)urea

Guidance literature:: In acetonitrile; at 23 ℃; for 0.5h;
DOI:10.1016/j.bmc.2011.05.057

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1222386-18-6
N-{2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N'-(4-chlorophenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 24 h / 23 °C

2.1: sodium dithionite; water; potassium carbonate / ethanol / 0.5 h / 23 °C

2.2: pH 3

2.3: pH 10

3.1: acetic acid / methanol / 0.17 h / 23 °C

3.2: 3 h / 23 °C

4.1: ethyl acetate / 2 h / Reflux

5.1: acetic acid; zinc / 0.25 h / 23 °C

5.2: pH 10

6.1: acetonitrile / 0.5 h / 23 °C

With sodium dithionite; water; potassium carbonate; acetic acid; zinc; In tetrahydrofuran; methanol; ethanol; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2011.05.057

Reference yield:

: 163618-10-8
N-(3-methyl-1-butyl)-N'-[2-(morpholin-4-yl)ethyl]-1,2-phenylenediamine

: 1222386-18-6
N-{2,4-dioxo-1-(3-methyl-1-butyl)-5-[2-(morpholin-4-yl)ethyl]-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl}-N'-(4-chlorophenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl acetate / 2 h / Reflux

2.1: acetic acid; zinc / 0.25 h / 23 °C

2.2: pH 10

3.1: acetonitrile / 0.5 h / 23 °C

With acetic acid; zinc; In ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2011.05.057