5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one

Base Information

Chemical Name:5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one
CAS No.:1373243-45-8
Molecular Formula:C₂₆H₂₁FN₂O₄
Molecular Weight:444.462
Hs Code.:

Synonyms:5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one

Suppliers and Price of 5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one

There total 7 articles about 5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1373243-44-7
6'-hydroxy-1'-methylspiro[cyclopropane-1,3'-indolin]-2'-one

: 313245-18-0
(1-(4-fluoro-benzyl)-1H-indole-2,3-dione)

: 1373243-45-8
5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one

Guidance literature:: 6'-hydroxy-1'-methylspiro[cyclopropane-1,3'-indolin]-2'-one; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃;

(1-(4-fluoro-benzyl)-1H-indole-2,3-dione); In tetrahydrofuran; at 70 ℃; for 24h; Reflux;

Reference yield:

: 368834-85-9
6'-methoxy-1'-methylspiro[cyclopropane-1,3'-indolin]-2'-one

: 1373243-45-8
5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 2.5 h / -78 - 0 °C

1.2: -78 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0 °C

2.2: 24 h / 70 °C / Reflux

With isopropylmagnesium chloride; boron tribromide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1373243-45-8
5'-(1-(4-fluorobenzyl)-3-hydroxy-2-oxoindolin-3-yl)-6'-hydroxy-1'-methyl spiro[cyclopropane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0 °C

2.2: 24 h / 70 °C / Reflux

With isopropylmagnesium chloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;