5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite

Base Information

Chemical Name:5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite
CAS No.:112475-39-5
Molecular Formula:C₄₀H₄₇N₄O₉P
Molecular Weight:758.808
Hs Code.:

Synonyms:5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite

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Technology Process of 5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite

There total 6 articles about 5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-24-7
acetic anhydride

: 112475-36-2
5'-O-monomethoxytritylarabinouridine-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite

: 112475-39-5
5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 0.75h; Ambient temperature;

Reference yield: 50.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 122591-36-0
1-(2-O-acetyl-5-O-monomethoxytrityl-β-D-arabinofuranosyl)-uracil

: 112475-39-5
5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 2h; Ambient temperature;

Reference yield:

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 112475-39-5
5'-O-monomethoxytritylarabinouridine-2'-O-acetyl-3'-O-N,N-diisopropyl-β-cyanoethylphosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / diisopropylethylamine / tetrahydrofuran / 2 h / Ambient temperature

2: 95 percent / 4-dimethylaminopyridine, diisopropylethylamine / tetrahydrofuran / 0.75 h / Ambient temperature

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;