Technology Process of 2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-7-fluoro-1,3-benzoxazol-6-ol
There total 6 articles about 2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-7-fluoro-1,3-benzoxazol-6-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-3-fluorobenzamide;
With
palladium 10% on activated carbon; hydrogen;
In
tetrahydrofuran; water;
at 20 ℃;
for 0.333333h;
With
triethylamine; triphenylphosphine;
In
hexachloroethane; acetonitrile;
at 0 - 80 ℃;
for 1.25h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / methanol / 24 h / Reflux
1.2: 1 h / 70 °C
1.3: 2 h / 50 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C
2.2: 0.5 h / 20 °C
3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; water / 0.33 h / 20 °C
3.2: 1.25 h / 0 - 80 °C
With
oxalyl dichloride; sulfuric acid; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 0.5 h / 80 °C
2.1: iron(III) chloride; iron / ethanol
3.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C
3.2: 0.5 h / 20 °C
4.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; water / 0.33 h / 20 °C
4.2: 1.25 h / 0 - 80 °C
With
iron(III) chloride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; iron; sodium hydride; N,N-dimethyl-formamide;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
