(3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester

Base Information

Chemical Name:(3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester
CAS No.:110330-12-6
Molecular Formula:C₆₅H₈₈O₁₂S₂
Molecular Weight:1125.54
Hs Code.:

(3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester

Synonyms:(3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester

Suppliers and Price of (3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester

There total 22 articles about (3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110314-58-4
(2R,3R,4R,5S,8S)-8--1,2-epoxy-8-methoxy-4-(p-methoxybenzyloxy)-3,5-dimethyloctane

: 110330-12-6
(3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: n-BuLi, TMEDA / tetrahydrofuran / 1.) -20 deg C, 2.5 d, 2.) -20 deg C, 24 h

2: 1.) t-Bu(Me)2SiCl, imidazole, 2.) (COCl)2, 3.) DMAP / 1.) DMF, 45 deg C, 18 h, 2.) DMF, CH₂Cl₂, 0 deg C to r.t., 3.) pyridine r.t., 18 h

3: (n-Bu)4NF / tetrahydrofuran / 72 h / Ambient temperature

4: (i-Pr)2EtN / CH₂Cl₂ / 36 h / Ambient temperature

5: acetic acid; tetrahydrofuran; H₂O / 5.5 h / 55 °C

With 1H-imidazole; dmap; n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; di-tert-butyl(methyl)silyl chloride; In tetrahydrofuran; dichloromethane; water; acetic acid;
DOI:10.1021/ja00254a062

Reference yield:

: C₇₀H₉₆O₁₃S₂

: 110330-12-6
(3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester

Guidance literature:: In tetrahydrofuran; water; acetic acid; at 55 ℃; for 5.5h; Yield given;
DOI:10.1021/ja00254a062

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 110330-12-6
(3R,4R)-4-Benzyloxymethoxy-3-(4-methoxy-benzyloxy)-pentanoic acid (1S,2S,3R,4S,7S)-7-(3-benzyloxymethoxy-phenyl)-1-[2-((R)-4-hydroxy-1,1,3-trimethyl-butyl)-[1,3]dithian-2-ylmethyl]-7-methoxy-3-(4-methoxy-benzyloxy)-2,4-dimethyl-heptyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (i-Pr)2EtN / CH₂Cl₂ / 36 h / Ambient temperature

2: acetic acid; tetrahydrofuran; H₂O / 5.5 h / 55 °C

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetic acid;
DOI:10.1021/ja00254a062