(S)-2-phenylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-phenylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1042690-44-7
Molecular Formula:C₁₇H₂₄N₂O₃
Molecular Weight:304.389
Hs Code.:

Synonyms:(S)-2-phenylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-phenylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-2-phenylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about (S)-2-phenylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 75844-69-8
t-butyl piperidinecarboxylate

: 103-71-9
phenyl isocyanate

: 1042690-44-7
(S)-2-phenylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: t-butyl piperidinecarboxylate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at -78 ℃; for 3h; Inert atmosphere;

With C₁₂H₂₄N₂O^(2-)*2Li⁽¹⁺⁾; In diethyl ether; cyclohexane; at -45 ℃; for 3h; Inert atmosphere;

phenyl isocyanate; In diethyl ether; cyclohexane; at -78 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja105772z

Reference yield: 35.0%

: 1042690-44-7
(S)-2-phenylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:

Reference yield:

: 109-72-8,29786-93-4
n-butyllithium

: 103-71-9
phenyl isocyanate

: 123387-55-3,1000075-49-9,1078727-67-9
1-t-butoxycarbonyl-2-tributylstannylpiperidine

: 1042690-44-7
(S)-2-phenylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester

: 1217352-18-5
(R)-N-Boc-piperidine-2-carboxylic acid phenyl amide

: 10264-18-3
N-phenylpentanamide

Guidance literature:: n-butyllithium; 1-t-butoxycarbonyl-2-tributylstannylpiperidine; With N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -78 ℃; for 1h; Inert atmosphere;

With C₁₁H₂₁N₂O^(1-)*Li⁽¹⁺⁾; In diethyl ether; at -55 ℃; for 4h; Inert atmosphere;

phenyl isocyanate; In diethyl ether; at -78 ℃; Overall yield = 71 %; Inert atmosphere;
DOI:10.1021/ja307796e