N-phenyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,9-diazaspiro[2.6]nonane-9-carbothioamide

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Chemical Name:N-phenyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,9-diazaspiro[2.6]nonane-9-carbothioamide
CAS No.:1354624-68-2
Molecular Formula:C₂₀H₂₂N₆S
Molecular Weight:378.501
Hs Code.:

Synonyms:N-phenyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,9-diazaspiro[2.6]nonane-9-carbothioamide

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Chemical Property of N-phenyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,9-diazaspiro[2.6]nonane-9-carbothioamide

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Technology Process of N-phenyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,9-diazaspiro[2.6]nonane-9-carbothioamide

There total 7 articles about N-phenyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,9-diazaspiro[2.6]nonane-9-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354623-69-0
4-(5,9-diazaspiro[2.6]nonan-5-yl)-7H-pyrrolo[2,3-d]pyrimidine

: 103-72-0
phenyl isothiocyanate

: 1354624-68-2
N-phenyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,9-diazaspiro[2.6]nonane-9-carbothioamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 179686-38-5
tert-butyl 3-oxo-1,4-diazepane-1-carboxylate

: 1354624-68-2
N-phenyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,9-diazaspiro[2.6]nonane-9-carbothioamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 °C

1.2: 5 h / 20 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / -78 - 20 °C / Reflux

3.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

4.1: potassium carbonate / water / 16 h / Reflux

5.1: ammonium formate / palladium 10% on activated carbon / methanol / 1.5 h / Reflux

6.1: tetrahydrofuran / 16 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; ammonium formate; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 1354623-65-6
tert-butyl 4-benzyl-3-oxo-1,4-diazepane-1-carboxylate

: 1354624-68-2
N-phenyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,9-diazaspiro[2.6]nonane-9-carbothioamide

Guidance literature:: Multi-step reaction with 5 steps

1: titanium(IV) isopropylate / tetrahydrofuran / -78 - 20 °C / Reflux

2: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

3: potassium carbonate / water / 16 h / Reflux

4: ammonium formate / palladium 10% on activated carbon / methanol / 1.5 h / Reflux

5: tetrahydrofuran / 16 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; ammonium formate; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water;