1-N-((2''''R)-4''''-carboxybenzylamino-2''''-hydroxybutanoyl)-3',4',3''',4'''-didehydro-3',4',3''',4'''-tetradeoxy-3,2',2''',6'''-penta-N-Cbz-paromomycin

Base Information

Chemical Name:1-N-((2''''R)-4''''-carboxybenzylamino-2''''-hydroxybutanoyl)-3',4',3''',4'''-didehydro-3',4',3''',4'''-tetradeoxy-3,2',2''',6'''-penta-N-Cbz-paromomycin
CAS No.:1335107-95-3
Molecular Formula:C₆₇H₇₈N₆O₂₂
Molecular Weight:1319.38
Hs Code.:

Synonyms:1-N-((2''''R)-4''''-carboxybenzylamino-2''''-hydroxybutanoyl)-3',4',3''',4'''-didehydro-3',4',3''',4'''-tetradeoxy-3,2',2''',6'''-penta-N-Cbz-paromomycin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-N-((2''''R)-4''''-carboxybenzylamino-2''''-hydroxybutanoyl)-3',4',3''',4'''-didehydro-3',4',3''',4'''-tetradeoxy-3,2',2''',6'''-penta-N-Cbz-paromomycin

Chemical Property:

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Technology Process of 1-N-((2''''R)-4''''-carboxybenzylamino-2''''-hydroxybutanoyl)-3',4',3''',4'''-didehydro-3',4',3''',4'''-tetradeoxy-3,2',2''',6'''-penta-N-Cbz-paromomycin

There total 1 articles about 1-N-((2''''R)-4''''-carboxybenzylamino-2''''-hydroxybutanoyl)-3',4',3''',4'''-didehydro-3',4',3''',4'''-tetradeoxy-3,2',2''',6'''-penta-N-Cbz-paromomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40371-50-4
S-4-benzyloxycarbonylamino-2-hydroxybutyric acid

: C₅₅H₆₅N₅O₁₈

: 1335107-95-3
1-N-((2''''R)-4''''-carboxybenzylamino-2''''-hydroxybutanoyl)-3',4',3''',4'''-didehydro-3',4',3''',4'''-tetradeoxy-3,2',2''',6'''-penta-N-Cbz-paromomycin

Guidance literature:: With 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ml200202y

Reference yield: 79.0%

: 1335107-95-3
1-N-((2''''R)-4''''-carboxybenzylamino-2''''-hydroxybutanoyl)-3',4',3''',4'''-didehydro-3',4',3''',4'''-tetradeoxy-3,2',2''',6'''-penta-N-Cbz-paromomycin

: 64-19-7,77671-22-8
acetic acid

: 1-N-((2''''R)-4''''-amino-2''''-hydroxybutanoyl)-3',4',3''',4'''-tetradeoxyparomomycin pentaacetic acid

Guidance literature:: 1-N-((2''''R)-4''''-carboxybenzylamino-2''''-hydroxybutanoyl)-3',4',3''',4'''-didehydro-3',4',3''',4'''-tetradeoxy-3,2',2''',6'''-penta-N-Cbz-paromomycin; With 20 % Pd(OH)2/C; hydrogen; acetic acid; In water; for 4h;

acetic acid; Inert atmosphere;
DOI:10.1021/ml200202y