(Z)-4-[(diisopropylphosphono)methoxy]-1-triphenylmethoxy-2-butene

Base Information

• Chemical Name: (Z)-4-[(diisopropylphosphono)methoxy]-1-triphenylmethoxy-2-butene
• CAS No.: 265322-90-5
• Molecular Formula: C₃₀H₃₇O₅P
• Molecular Weight: 508.595
• Mol file: 265322-90-5.mol

Synonyms:(Z)-4-[(diisopropylphosphono)methoxy]-1-triphenylmethoxy-2-butene

Chemical Property of (Z)-4-[(diisopropylphosphono)methoxy]-1-triphenylmethoxy-2-butene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (Z)-4-[(diisopropylphosphono)methoxy]-1-triphenylmethoxy-2-butene

There total 1 articles about (Z)-4-[(diisopropylphosphono)methoxy]-1-triphenylmethoxy-2-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate (35717-98-7) + (Ζ)-4-(triphenylmethoxy)-2-buten-1-ol (126027-87-0) → (Z)-4-[(diisopropylphosphono)methoxy]-1-triphenylmethoxy-2-butene (265322-90-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at -20 - 20 ℃;

DOI:10.1021/jm9911377

Reference yield:

(Z)-4-[(diisopropylphosphono)methoxy]-1-triphenylmethoxy-2-butene (265322-90-5) → [4-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-but-2-enyloxymethyl]-phosphonic acid diisopropyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 80percent aq. AcOH / 0.33 h / 60 °C

2: PPh₃; DIAD / tetrahydrofuran / 2 h / 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1: deprotection / 2: Condensation;

DOI:10.1021/jm9911377

upstream raw materials:

bis(2-propyl)-p-toluenesulfonyloxymethylphosphonate

(Ζ)-4-(triphenylmethoxy)-2-buten-1-ol