(4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol

Base Information

Chemical Name:(4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol
CAS No.:378197-91-2
Molecular Formula:C₃₂H₄₈O₂Si
Molecular Weight:492.817
Hs Code.:

Synonyms:(4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol

Suppliers and Price of (4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol

There total 2 articles about (4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 38419-75-9
(1R,2R,4aS,8aS)-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 378197-91-2
(4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jo010154c

Reference yield:

: 564-20-5,1216-84-8,30450-17-0,58976-28-6,64090-92-2,67844-42-2,79768-41-5,79768-42-6,86688-27-9,86688-28-0,95406-08-9,98719-44-9,98719-46-1,131831-65-7,140851-80-5
(3aR)-(+)-sclareolide

: 378197-91-2
(4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

2: 99 percent / imidazole / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo010154c

Reference yield: 62.0%

: 378197-91-2
(4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol

: 378197-93-4
(4aS,8aS,2R,4R)-4-(2-[tert-butyldiphenylsilyloxy]ethyl)-4a,8,8,trimethyl-3-methyleneperhydro-2-naphthalenol

Guidance literature:: (4aS,8aS,1R,2R)-1-(2-(tert-butyldiphenylsilyloxy)ethyl)-2,5,5,8a-tetramethylperhydro-2-naphthalenol; With dmap; thionyl chloride; In pyridine; at -50 - 0 ℃;

With tert.-butylhydroperoxide; selenium(IV) oxide; salicylic acid; In dichloromethane; at 20 ℃; for 48h; Further stages.;
DOI:10.1021/jo010154c