phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester

Base Information

Chemical Name:phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester
CAS No.:873782-92-4
Molecular Formula:C₅₇H₇₆N₃O₁₅P
Molecular Weight:1074.22
Hs Code.:

phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester

Synonyms:phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester

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Chemical Property of phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester

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Technology Process of phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester

There total 6 articles about phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873782-64-0
{6-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-16-ethyl-4-hydroxy-15-hydroxymethyl-5,9,13-trimethyl-2-oxo-10-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-11,13-dien-7-yl}-acetaldehyde

: 26386-88-9
diphenyl phosphoryl azide

: 873782-92-4
phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 476661-20-8
6-(3-bromo-propoxy)quinoline

: 873782-92-4
phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium t-butoxide / dimethylformamide

2: DBU / tetrahydrofuran

With potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.11.061

Reference yield:

: 873838-99-4
(11E,13E)-(4R,5S,6S,7R,9R,15R,16R)-6-((2R,3R,4S,5S,6R)-4-Dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-7-[1,3]dioxolan-2-ylmethyl-16-ethyl-4-hydroxy-15-hydroxymethyl-5,9,13-trimethyl-oxacyclohexadeca-11,13-diene-2,10-dione

: 873782-92-4
phosphoric acid 12-(4-dimethylamino-3,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-11-[1,3]dioxolan-2-ylmethyl-2-ethyl-14-hydroxy-5,9,13-trimethyl-16-oxo-8-[3-(quinolin-6-yloxy)-propoxyimino]-oxacyclohexadeca-4,6-dien-3-ylmethyl ester diphenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / methanol

2: potassium t-butoxide / dimethylformamide

3: DBU / tetrahydrofuran

With pyridine; potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.11.061