N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide

Base Information

Chemical Name:N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide
CAS No.:1431533-18-4
Molecular Formula:C₃₁H₂₆F₃NO₄
Molecular Weight:533.547
Hs Code.:

Synonyms:N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide

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Chemical Property of N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide

Chemical Property:

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Technology Process of N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide

There total 5 articles about N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431533-13-9
2,4-bis(benzyloxy)-3-fluoroaniline

: 1431533-17-3
4-(cyclopropylmethoxy)-2,3-difluorobenzoic acid

: 1431533-18-4
N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide

Guidance literature:: 4-(cyclopropylmethoxy)-2,3-difluorobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Reflux;

2,4-bis(benzyloxy)-3-fluoroaniline; With pyridine;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1431533-18-4
N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 0.5 h / 80 °C

2.1: iron(III) chloride; iron / ethanol

3.1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 20 °C / Reflux

With iron(III) chloride; oxalyl dichloride; iron; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 771-69-7
2,3,4-trifluoronitrobenzene

: 1431533-18-4
N-(2,4-bis(benzyloxy)-3-fluorophenyl)-4-(cyclopropylmethoxy)-2,3-difluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 0.5 h / 80 °C

2.1: iron(III) chloride; iron / ethanol

3.1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 20 °C / Reflux

With iron(III) chloride; oxalyl dichloride; iron; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;