9a-(4-chloro-benzyl)-7-methoxy-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,9,9a-tetrahydro-fluoren-3-one

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Chemical Name:9a-(4-chloro-benzyl)-7-methoxy-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,9,9a-tetrahydro-fluoren-3-one
CAS No.:851107-71-6
Molecular Formula:C₃₄H₃₆ClNO₃
Molecular Weight:542.118
Hs Code.:

Synonyms:9a-(4-chloro-benzyl)-7-methoxy-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,9,9a-tetrahydro-fluoren-3-one

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Chemical Property of 9a-(4-chloro-benzyl)-7-methoxy-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,9,9a-tetrahydro-fluoren-3-one

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Technology Process of 9a-(4-chloro-benzyl)-7-methoxy-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,9,9a-tetrahydro-fluoren-3-one

There total 10 articles about 9a-(4-chloro-benzyl)-7-methoxy-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,9,9a-tetrahydro-fluoren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 3040-44-6
1-piperidinoethanol

: 851107-70-5
9a-(4-chlorobenzyl)-4-(4-hydroxyphenyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one

: 851107-71-6
9a-(4-chloro-benzyl)-7-methoxy-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,9,9a-tetrahydro-fluoren-3-one

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 48h;
DOI:10.1021/ja209933r

Reference yield:

: 851107-68-1
4-bromo-9a-(4-chlorobenzyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one

: 851107-71-6
9a-(4-chloro-benzyl)-7-methoxy-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,9,9a-tetrahydro-fluoren-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine)-palladium⁽⁰⁾ / toluene / 24 h / 100 °C

2: aq. HCl / methanol / 1 h / 80 °C

3: triphenylphosphine; DIAD / tetrahydrofuran / 7 h / 0 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; toluene; 1: Stille coupling;
DOI:10.1021/jm060516e

Reference yield:

: 851107-67-0
9a-(4-chloro-benzyl)-7-methoxy-1,2,9,9a-tetrahydro-fluoren-3-one

: 851107-71-6
9a-(4-chloro-benzyl)-7-methoxy-4-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,9,9a-tetrahydro-fluoren-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

2: tetrakis(triphenylphosphine)-palladium⁽⁰⁾ / toluene / 24 h / 100 °C

3: aq. HCl / methanol / 1 h / 80 °C

4: triphenylphosphine; DIAD / tetrahydrofuran / 7 h / 0 - 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; bromine; sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; toluene; 2: Stille coupling;
DOI:10.1021/jm060516e