7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine

Base Information

Chemical Name:7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine
CAS No.:1384951-03-4
Molecular Formula:C₂₃H₂₄FN₅O₄S₂
Molecular Weight:517.605
Hs Code.:

Synonyms:7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine

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Chemical Property of 7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine

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Technology Process of 7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine

There total 12 articles about 7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 832714-37-1
1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-ol

: 1384951-73-8
7-(2-fluoro-4-methanesulfonylphenyl)-4-(methanesulfonyl)thieno[3,2-d]pyrimidine

: 1384951-03-4
7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine

Guidance literature:: 1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

7-(2-fluoro-4-methanesulfonylphenyl)-4-(methanesulfonyl)thieno[3,2-d]pyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 31169-27-4
7-bromo-4-chlorothieno[3,2-d]pyrimidine

: 1384951-03-4
7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 13 h / 10 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

3.2: 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 2 h / 20 °C

With sodium hydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 1384951-03-4
7-(2-fluoro-4-methanesulfonylphenyl)-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / L-proline; copper(l) iodide / dimethyl sulfoxide / 24 h / 90 °C / Sealed tube

2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 1 h / 65 °C

3.1: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 90 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C

5.2: 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.2: 2 h / 20 °C

With tert.-butylnitrite; potassium acetate; sodium hydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; copper(ll) bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; L-proline; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;