(2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol

Base Information

Chemical Name:(2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol
CAS No.:275816-94-9
Molecular Formula:C₂₅H₃₆O₅Si
Molecular Weight:444.643
Hs Code.:

Synonyms:(2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol

Suppliers and Price of (2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol

There total 1 articles about (2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-(4-methoxyphenyl)-2-butenal

: 275816-94-9
(2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 0.666667h;
DOI:10.3987/com-99-8839

Reference yield: 100.0%

: 79-22-1
methyl chloroformate

: 275816-94-9
(2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol

: 275816-95-0
(2Z)-1-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-4-methoxycarbonyloxy-2-(4-methoxyphenyl)-2-butene

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.3987/com-99-8839

Reference yield:

: 275816-94-9
(2Z)-4-(6-tert-butyldimethylsilyloxy-2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-buten-1-ol

: 136850-29-8,136850-45-8
3-<4,6-dimethoxy-2-(4-methoxyphenyl)-3-oxo-2,3-dihydrobenzofuran-2-yl>-3-phenylpropanal

Guidance literature:: Multi-step reaction with 11 steps

1: 100 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.25 h / 0 °C

3: 100 percent / Pd(PPh₃)4 / acetonitrile / 2 h / 20 °C

4: 100 percent / aq. OsO₄; NMO / tetrahydrofuran / 20 h / 20 °C

5: 96 percent / aq. NaIO₄ / tetrahydrofuran / 1 h / 20 °C

6: 72 percent / tetrahydrofuran / 0.5 h / 0 °C

7: 100 percent / TPAP; NMO; 4 Angstroem MS / CH₂Cl₂ / 1 h / 20 °C

8: 100 percent / NaH / tetrahydrofuran / 3 h / 80 °C

9: 100 percent / H₂ / 10 percent Pd/C / ethyl acetate / 4 h / 20 °C

10: 100 percent / DIBALH / CH₂Cl₂; hexane / 0.33 h / -78 °C

11: 80 percent / DDQ / dioxane / 0.67 h / 20 °C

With pyridine; sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 Angstroem MS; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisobutylaluminium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; ethyl acetate; acetonitrile; 1: Esterification / 2: desilylation / 3: Cyclization / 4: Oxidation / 5: Oxidation / 6: Grignard reaction / 7: Oxidation / 8: Wadsworth-Emmons reaction / 9: Catalytic hydrogenation / 10: Reduction / 11: Oxidation;
DOI:10.3987/com-99-8839