(4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one

Base Information

Chemical Name:(4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one
CAS No.:1616376-34-1
Molecular Formula:C₂₅H₃₁NO₅
Molecular Weight:425.525
Hs Code.:

Synonyms:(4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one

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Chemical Property of (4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one

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Technology Process of (4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one

There total 4 articles about (4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616376-28-3
C₁₃H₁₇F₃O₅S

: 352438-07-4
⁽⁴⁵⁾-3-propionyl-4-benzyl-2-oxazolidinone

: 1616376-34-1
(4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one

Guidance literature:: ⁽⁴⁵⁾-3-propionyl-4-benzyl-2-oxazolidinone; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

C₁₃H₁₇F₃O₅S; In tetrahydrofuran; at -78 - 0 ℃; for 5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo500906v

Reference yield:

: 160238-45-9
(2S)-3-(4-methoxybenzyloxy)-2-methyl-1-propanol

: 1616376-34-1
(4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

2.2: 5 h / -78 - 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2.1: |Evans Aldol Reaction / 2.2: |Evans Aldol Reaction;
DOI:10.1021/jo500906v

Reference yield:

: 212051-35-9
(R)-methyl 3-((4-methoxybenzyl)oxy)-2-methylpropanoate

: 1616376-34-1
(4S)-4-benzyl-3-((2R,4S)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5.5 h / 0 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 5 h / -78 - 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 3.1: |Evans Aldol Reaction / 3.2: |Evans Aldol Reaction;
DOI:10.1021/jo500906v