1-[3',5'-di(O-tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine

Base Information

• Chemical Name: 1-[3',5'-di(O-tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine
• CAS No.: 1251917-73-3
• Molecular Formula: C₄₂H₅₉N₃O₇Si₂
• Molecular Weight: 774.117

Synonyms:1-[3',5'-di(O-tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine

Chemical Property of 1-[3',5'-di(O-tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine

Chemical Property:

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Technology Process of 1-[3',5'-di(O-tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine

There total 1 articles about 1-[3',5'-di(O-tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-[3',5'-di(O-tert-butyldimethylsilyl)-β-D-arabinofuranosyl]cytosine (82845-96-3) → 1-[3',5'-di(O-tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine (1251917-73-3)

Guidance literature:

With pyridine; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2010.07.024

Reference yield: 89.0%

1-[3',5'-di(O-tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine (1251917-73-3) → 1-[3'-O-(tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine (1251917-74-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2010.07.024

Reference yield:

1-[3',5'-di(O-tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine (1251917-73-3) + tetradecanoyl chloride (112-64-1) → 1-[3',5'-di-(O-tert-butyldimethylsilyl)-2'-O-myristoyl-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine (1251917-83-5)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.ejmech.2010.07.024

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-[3',5'-di(O-tert-butyldimethylsilyl)-β-D-arabinofuranosyl]cytosine

Downstream raw materials:

1-[3'-O-(tert-butyldimethylsilyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine

1-[3',5'-di-(O-tert-butyldimethylsilyl)-2'-O-myristoyl-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine

1-[3',5'-di(O-tert-butyldimethylsilyl)-2'-O-(12-thioethyldodecanoyl)-N-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl]cytosine

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