2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol

Base Information

Chemical Name:2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol
CAS No.:838856-70-5
Molecular Formula:C₁₉H₁₁ClF₃N₃O₃
Molecular Weight:421.763
Hs Code.:

Synonyms:2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol

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Chemical Property of 2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol

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Technology Process of 2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol

There total 5 articles about 2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 838856-31-8
5-chloro-2-fluoro-4-hydroxybenzaldehyde

: 838856-76-1
4-(5,8-difluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-3-methyl-1H-pyrazol-5-amine

: 838856-70-5
2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol

Guidance literature:: With zinc trifluoromethanesulfonate; In 1,2-dichloro-ethane; acetonitrile; at 120 ℃; for 144h;

Reference yield:

: 72912-52-8
(5,8-difluoro-2,3-dihydro-1,4-benzodioxin-6-yl)acetonitrile

: 838856-70-5
2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 - 40 °C

1.2: 0.08 h / 40 °C

2.1: hydrazine dihydrochloride; triethylamine / ethanol / 6 h / 75 °C

3.1: zinc trifluoromethanesulfonate / 1,2-dichloro-ethane; acetonitrile / 144 h / 120 °C

With hydrazine dihydrochloride; zinc trifluoromethanesulfonate; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: C₁₂H₉F₂NO₃

: 838856-70-5
2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine dihydrochloride; triethylamine / ethanol / 6 h / 75 °C

2: zinc trifluoromethanesulfonate / 1,2-dichloro-ethane; acetonitrile / 144 h / 120 °C

With hydrazine dihydrochloride; zinc trifluoromethanesulfonate; triethylamine; In ethanol; 1,2-dichloro-ethane; acetonitrile;