Technology Process of 2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol
There total 5 articles about 2-chloro-4-(6,11-difluoro-1-methyl-8,9-dihydro-3H-[1,4]dioxino[2,3-g]pyrazolo[3,4-c]isoquinolin-5-yl)-5-fluorophenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
zinc trifluoromethanesulfonate;
In
1,2-dichloro-ethane; acetonitrile;
at 120 ℃;
for 144h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.17 h / 0 - 40 °C
1.2: 0.08 h / 40 °C
2.1: hydrazine dihydrochloride; triethylamine / ethanol / 6 h / 75 °C
3.1: zinc trifluoromethanesulfonate / 1,2-dichloro-ethane; acetonitrile / 144 h / 120 °C
With
hydrazine dihydrochloride; zinc trifluoromethanesulfonate; sodium hydride; triethylamine;
In
tetrahydrofuran; ethanol; 1,2-dichloro-ethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrazine dihydrochloride; triethylamine / ethanol / 6 h / 75 °C
2: zinc trifluoromethanesulfonate / 1,2-dichloro-ethane; acetonitrile / 144 h / 120 °C
With
hydrazine dihydrochloride; zinc trifluoromethanesulfonate; triethylamine;
In
ethanol; 1,2-dichloro-ethane; acetonitrile;