Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanone

Base Information

• Chemical Name: Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanone
• CAS No.: 170939-87-4
• Molecular Formula: C₂₃H₁₆ClNO
• Molecular Weight: 357.839
• Mol file: 170939-87-4.mol

Synonyms:Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanone

Chemical Property of Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanone

There total 1 articles about Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(E)-1-([1,1'-biphenyl]-4-yl)-3-(4-chlorophenyl)prop-2-en-1-one (132434-50-5) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanone (170939-87-4)

Guidance literature:

With sodium hydride; In diethyl ether; dimethyl sulfoxide; for 0.0833333h; Ambient temperature;

DOI:10.1021/jm00021a011

Reference yield: 96.0%

Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanone (170939-87-4) → Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanol

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1021/jm00021a011

Reference yield:

Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methanone (170939-87-4) → 1-{Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methyl}-1H-imidazole (170938-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

2: 100 percent / acetonitrile / 1.5 h / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm00021a011

upstream raw materials:

(E)-1-([1,1'-biphenyl]-4-yl)-3-(4-chlorophenyl)prop-2-en-1-one

[(p-methylphenyl)sulfonylmethyl]isonitrile

Downstream raw materials:

1-{Biphenyl-4-yl-[4-(4-chloro-phenyl)-1H-pyrrol-3-yl]-methyl}-1H-imidazole