[(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl]-methanol

Base Information

Chemical Name:[(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl]-methanol
CAS No.:96246-64-9
Molecular Formula:C₁₅H₁₈N₂O₄
Molecular Weight:290.319
Hs Code.:

Synonyms:[(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl]-methanol

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Chemical Property of [(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl]-methanol

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Technology Process of [(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl]-methanol

There total 3 articles about [(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 96246-62-7
(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizine-1-carboxylic acid methyl ester

: 96246-64-9
[(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl]-methanol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -23 ℃; for 1h;
DOI:10.1021/jo00212a034

Reference yield:

: 96246-60-5
7-(2-Nitro-benzyloxy)-2,5,6,7-tetrahydro-3H-pyrrolizine-1-carboxylic acid methyl ester

: 96246-64-9
[(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) diisobutylaluminum hydride / 1.) THF/hexane, -45 deg C, 1 h 2.) -78 deg C, 15 min.

2: 1.) m-chloroperbenzoic acid 2.) dimethyl sulfide / 1.) methylene chloride, - 78 deg C, 2 h 2.) 1 h

3: 100 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 1 h / -23 °C

With dimethylsulfide; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In hexane; dichloromethane;
DOI:10.1021/jo00212a034

Reference yield:

: 96246-61-6
(7R,7aS)-7-(2-Nitro-benzyloxy)-1-phenylselanyl-hexahydro-pyrrolizine-1-carboxylic acid methyl ester

: 96246-64-9
[(7R,7aR)-7-(2-Nitro-benzyloxy)-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-yl]-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) m-chloroperbenzoic acid 2.) dimethyl sulfide / 1.) methylene chloride, - 78 deg C, 2 h 2.) 1 h

2: 100 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 1 h / -23 °C

With dimethylsulfide; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In hexane; dichloromethane;
DOI:10.1021/jo00212a034