(S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate

Base Information

Chemical Name:(S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate
CAS No.:1176235-04-3
Molecular Formula:C₃₆H₃₆N₂O₃S
Molecular Weight:576.759
Hs Code.:

Synonyms:(S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate

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Chemical Property of (S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate

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Technology Process of (S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate

There total 4 articles about (S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 115545-85-2
(S)-2-amino-3-(tritylmercapto)propionic acid methyl ester

: 15542-38-8
(2E,4E)-5-[4-(dimethylamino)phenyl]-2,4-pentadienoic acid

: 1176235-04-3
(S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tet.2013.03.050

Reference yield:

: 20432-35-3,6203-18-5
3-(4-dimethylamino-phenyl)-propenal

: 1176235-04-3
(S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 5 h / 20 °C

2: sodium hydroxide / isopropyl alcohol / 5 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1: |Wittig Olefination;
DOI:10.1016/j.tet.2013.03.050

Reference yield:

: 16913-49-8
5-<4-(dimethylamino)phenyl>-2,4-pentadienoic acid ethyl ester

: 1176235-04-3
(S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / isopropyl alcohol / 5 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.tet.2013.03.050