5-(5-fluoro-2-pyridyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one

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Chemical Name:5-(5-fluoro-2-pyridyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one
CAS No.:1382782-16-2
Molecular Formula:C₁₈H₁₅FN₄O₂
Molecular Weight:338.341
Hs Code.:

Synonyms:5-(5-fluoro-2-pyridyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one

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Chemical Property of 5-(5-fluoro-2-pyridyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one

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Technology Process of 5-(5-fluoro-2-pyridyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one

There total 6 articles about 5-(5-fluoro-2-pyridyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 41404-58-4
2-bromo-5-fluoropyridine

: 1382782-07-1
2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

: 1382782-16-2
5-(5-fluoro-2-pyridyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 120 ℃; for 60h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.bmcl.2015.11.098

Reference yield:

: C₁₅H₁₉N₃O₃

: 1382782-16-2
5-(5-fluoro-2-pyridyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; water / 1,4-dioxane / 48 h / 20 °C

2: potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 60 h / 120 °C / Inert atmosphere; Sealed tube

With copper(l) iodide; water; sodium carbonate; potassium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; toluene;
DOI:10.1016/j.bmcl.2015.11.098

Reference yield:

: 856256-82-1
3-(phenoxymethyl)-1H-pyrazole-5-carboxylic acid ethyl ester

: 1382782-16-2
5-(5-fluoro-2-pyridyl)-2-(phenoxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 16 h / 0 - 80 °C

2: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 20 °C

3: sodium carbonate; water / 1,4-dioxane / 48 h / 20 °C

4: potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 60 h / 120 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; copper(l) iodide; di-tert-butyl-diazodicarboxylate; water; sodium carbonate; potassium carbonate; triphenylphosphine; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1016/j.bmcl.2015.11.098