(S)-N-(1-amino-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-1-oxopropan-2-yl)-4-(tert-butyl)benzamide

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Chemical Name:(S)-N-(1-amino-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-1-oxopropan-2-yl)-4-(tert-butyl)benzamide
CAS No.:1443792-45-7
Molecular Formula:C₃₇H₄₄N₄O₃
Molecular Weight:592.781
Hs Code.:

Synonyms:(S)-N-(1-amino-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-1-oxopropan-2-yl)-4-(tert-butyl)benzamide

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Chemical Property of (S)-N-(1-amino-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-1-oxopropan-2-yl)-4-(tert-butyl)benzamide

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Technology Process of (S)-N-(1-amino-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-1-oxopropan-2-yl)-4-(tert-butyl)benzamide

There total 7 articles about (S)-N-(1-amino-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-1-oxopropan-2-yl)-4-(tert-butyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1443789-07-8
(S)-2-(4-(tert-butyl)benzamido)-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)propanoic acid

: 1443792-45-7
(S)-N-(1-amino-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-1-oxopropan-2-yl)-4-(tert-butyl)benzamide

Guidance literature:: With ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 1443792-06-0
(S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

: 1443792-45-7
(S)-N-(1-amino-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-1-oxopropan-2-yl)-4-(tert-butyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate decahydrate / water / 5 h / Reflux

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate / water; tetrahydrofuran; acetonitrile / 0.83 h / 110 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogen; palladium on activated charcoal / ethyl acetate

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

4.2: 2 h

5.1: N-ethyl-N,N-diisopropylamine; HATU; ammonium chloride / N,N-dimethyl-formamide

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate decahydrate; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1443792-07-1
(S)-tert-butyl 2-(((benzyloxy)carbonyl)amino)-3-(4-(5-bromopyrimidin-2-yl)phenyl)propanoate

: 1443792-45-7
(S)-N-(1-amino-3-(4-(5-(4-(heptyloxy)phenyl)pyrimidin-2-yl)phenyl)-1-oxopropan-2-yl)-4-(tert-butyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate / water; tetrahydrofuran; acetonitrile / 0.83 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: hydrogen; palladium on activated charcoal / ethyl acetate

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

3.2: 2 h

4.1: N-ethyl-N,N-diisopropylamine; HATU; ammonium chloride / N,N-dimethyl-formamide

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;