(1R,2R,3S)-3-tert-butyl (1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-2-phenylcyclopropanecarboxylate

Base Information

Chemical Name:(1R,2R,3S)-3-tert-butyl (1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-2-phenylcyclopropanecarboxylate
CAS No.:188399-73-7
Molecular Formula:C₂₂H₃₃N₂O₃P
Molecular Weight:404.489
Hs Code.:

Synonyms:(1R,2R,3S)-3-tert-butyl (1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-2-phenylcyclopropanecarboxylate

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Chemical Property of (1R,2R,3S)-3-tert-butyl (1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-2-phenylcyclopropanecarboxylate

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Technology Process of (1R,2R,3S)-3-tert-butyl (1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-2-phenylcyclopropanecarboxylate

There total 1 articles about (1R,2R,3S)-3-tert-butyl (1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-2-phenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 14990-09-1
tert-butyl cinnamate

: 132008-90-3
(3aR,7aR)-2-Chloromethyl-1,3-dimethyl-octahydro-benzo[1,3,2]diazaphosphole 2-oxide

: 188399-73-7
(1R,2R,3S)-3-tert-butyl (1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-2-phenylcyclopropanecarboxylate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/S0040-4039(96)02518-X

Reference yield: 84.0%

: 188399-73-7
(1R,2R,3S)-3-tert-butyl (1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-2-phenylcyclopropanecarboxylate

: (1R,2S,3R)-[2-(1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-3-phenylcyclopropyl]methanol

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at -78 ℃; for 0.25h;
DOI:10.1016/j.bmc.2007.02.040

Reference yield:

: 188399-73-7
(1R,2R,3S)-3-tert-butyl (1,3-dimethyl-2-oxidooctahydro-1H-1,3,2-benzodiazaphosphol-2-yl)-2-phenylcyclopropanecarboxylate

: C₂₆H₃₄N₃O₂P

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / lithium triethylborohydride / tetrahydrofuran / 0.25 h / -78 °C

2: 38 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h / 20 °C

3: methanol / 24 h / 20 °C

With lithium triethylborohydride; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2007.02.040