8-Hydroxy-2-dipropylaminotetralin hydrobromide

Base Information

• Chemical Name: 8-Hydroxy-2-dipropylaminotetralin hydrobromide
• CAS No.: 87394-87-4
• Deprecated CAS: 87394-87-4,139540-53-7
• Molecular Formula: BrH*C₁₆H₂₅NO
• Molecular Weight: 328.293
• European Community (EC) Number: 635-844-4
• UNII: G8TFV2F5CP
• DSSTox Substance ID: DTXSID80896822
• Wikidata: Q27278948
• ChEMBL ID: CHEMBL505765
• Mol file: 87394-87-4.mol

Synonyms:8-Hydroxy-2-(di-n-propylamino)tetralin;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (+-)-Isomer;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (R)-Isomer,;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrobromide, (S)-Isomer,;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrochloride, (R)-Isomer,;8-Hydroxy-2-(di-n-propylamino)tetralin Hydrochloride, (S)-Isomer;8-Hydroxy-2-(di-n-propylamino)tetralin, (+-)-Isomer;8-Hydroxy-2-(di-n-propylamino)tetralin, (R)-Isomer;8-Hydroxy-2-(di-n-propylamino)tetralin, (S)-Isomer;8-OH-DPAT

Chemical Property of 8-Hydroxy-2-dipropylaminotetralin hydrobromide

Chemical Property:

• PSA: 23.47000
• LogP: 4.32960
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 327.11978
• Heavy Atom Count: 19
• Complexity: 237

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Hydroxy-DPAT hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O.Br
• Uses: (±)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide is a potent and selective 5-hydroxytryptamine (5HT1A)-receptor agonist which is generally used as the standard in pharmacological studies.

Technology Process of 8-Hydroxy-2-dipropylaminotetralin hydrobromide

There total 8 articles about 8-Hydroxy-2-dipropylaminotetralin hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine; hydrochloride (78095-31-5,78095-34-8,81185-05-9,87394-86-3) → (+)-8-hydroxy-2(di-N-propylamino)-tetralin hydrobromide (76135-31-4,78095-19-9,78095-20-2,87394-87-4)

Guidance literature:

With hydrogen bromide;

DOI:10.1021/jm00140a002

Reference yield: 82.0%

(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine; hydrochloride (78095-31-5,78095-34-8,81185-05-9,87394-86-3) → (-)-8-hydroxy-2-(di-n-propylamino)tetralin*HBr (76135-31-4,78095-19-9,78095-20-2,87394-87-4)

Guidance literature:

With hydrogen bromide;

DOI:10.1021/jm00140a002

Reference yield:

N-benzyl-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (81185-19-5) → (+)-8-hydroxy-2(di-N-propylamino)-tetralin hydrobromide (76135-31-4,78095-19-9,78095-20-2,87394-87-4)

Guidance literature:

Multi-step reaction with 4 steps

3: 2.) LiAlH₄

4: 89 percent / 48percent aq. HBr

With lithium aluminium tetrahydride; hydrogen bromide;

DOI:10.1021/jm00140a002

upstream raw materials:

(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine; hydrochloride

(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine; hydrochloride

N-benzyl-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Benzyl-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine

Refernces