Tyrphostin AG 835

Base Information

Chemical Name:Tyrphostin AG 835
CAS No.:133550-37-5
Molecular Formula:C₁₈H₁₆N₂O₃
Molecular Weight:308.337
Hs Code.:
European Community (EC) Number:835-467-7
DSSTox Substance ID:DTXSID101017645
Nikkaji Number:J412.913J
NCI Thesaurus Code:C1781
ChEMBL ID:CHEMBL261557
Mol file:133550-37-5.mol

Synonyms:Tyrphostin AG 835;133550-37-5;Tyrphostin B44, (+) enantiomer;Tyrphostin B50;(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide;(+)-Tyrphostin B44;(S,E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)acrylamide;(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide;TYRPHOSTINAG835;MFCD00209855;Tyrphostin Ag-835;tyrphostin-AG-835;Tocris-0579;Tyrphostin deriv. 50;Lopac-T-4443;Lopac-T-5568;Lopac0_001198;BDBM4305;CHEMBL261557;SCHEMBL12856415;Tyrphostin AG 835, >=92%;DTXSID101017645;HMS3263P17;HMS3266M20;HMS3414G21;HMS3678G21;Tox21_501198;(+)-(S)-N-(alpha-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide;HSCI1_000020;AKOS024458569;CCG-205272;HY-101007A;LP01198;SDCCGSBI-0051165.P002;NCGC00016022-01;NCGC00016022-02;NCGC00024663-01;NCGC00024663-02;NCGC00024663-03;NCGC00024663-04;NCGC00261883-01;AS-73062;CS-0020687;EU-0101198;T3540;D86748;T 5568;SR-01000597624;SR-01000597624-1;BRD-K17415526-001-02-7;(S)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)acrylamide;(S)-N-(alpha-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide;2-Cyano-3-(3,4-dihydroxyphenyl)-N-[(S)-1-phenylethyl]acrylamide;(+)-(S)-N-(alpha-Methylbenzyl)-3,4-dihydroxy-benzylidenecyanoacetamide;(2E)-2-Cyano-3-(3,4-Dihydroxyphenyl)-N-[(1S)-1-Phenylethyl]-2-Propenamide;(S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide;2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]-,(2E)-

Suppliers and Price of Tyrphostin AG 835

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TyrphostinB44,(+)enantiomer
10mg
$ 70.00

TRC
TyrphostinB44,(+)enantiomer
5mg
$ 45.00

Tocris
TyrphostinB44,(+)enantiomer
50
$ 465.00

Tocris
TyrphostinB44,(+)enantiomer
10
$ 111.00

TCI Chemical
Tyrphostin AG 835 >98.0%(HPLC)
25mg
$ 114.00

TCI Chemical
Tyrphostin AG 835 >98.0%(HPLC)
100mg
$ 313.00

Chem-Impex
TyrphostinAG835,≥98%(HPLC) ≥98%(HPLC)
100MG
$ 619.67

Chem-Impex
TyrphostinAG835,98%(HPLC) 98%(HPLC)
25MG
$ 183.68

ApexBio Technology
TyrphostinB44,(+)enantiomer
10mg
$ 188.00

ApexBio Technology
TyrphostinB44,(+)enantiomer
50mg
$ 795.00

Total 12 raw suppliers

Chemical Property of Tyrphostin AG 835

Chemical Property:

Vapor Pressure:3.9E-15mmHg at 25°C
Melting Point:146 °C
Boiling Point:603°Cat760mmHg
Flash Point:318.5°C
PSA：93.35000
Density:1.299g/cm³
LogP:3.27308
Storage Temp.:−20°C
Solubility.:DMSO or ethanol: soluble
XLogP3:2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:308.11609238
Heavy Atom Count:23
Complexity:488

Purity/Quality:

98%Min ^*data from raw suppliers

TyrphostinB44,(+)enantiomer ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
Isomeric SMILES:C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
Uses Tyrphostin B44, (+) enantiomer is an EGFR kinase inhibitor.

Technology Process of Tyrphostin AG 835

There total 2 articles about Tyrphostin AG 835 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%